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Prevention and management of COVID-19 among patients with diabetes: an appraisal of the literature

The coronavirus disease 2019 (COVID-19) pandemic has emerged as one of the greatest challenges faced by humankind in the recent past. People with diabetes and related comorbidities are at increased risk of its complications and of COVID-19-related death. Older age, multi-morbidity, hyperglycaemia, c...

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Autores principales: Katulanda, Prasad, Dissanayake, Harsha A., Ranathunga, Ishara, Ratnasamy, Vithiya, Wijewickrama, Piyumi S. A., Yogendranathan, Nilukshana, Gamage, Kavinga K. K., de Silva, Nipun L., Sumanatilleke, Manilka, Somasundaram, Noel P., Matthews, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220850/
https://www.ncbi.nlm.nih.gov/pubmed/32405783
http://dx.doi.org/10.1007/s00125-020-05164-x
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author Katulanda, Prasad
Dissanayake, Harsha A.
Ranathunga, Ishara
Ratnasamy, Vithiya
Wijewickrama, Piyumi S. A.
Yogendranathan, Nilukshana
Gamage, Kavinga K. K.
de Silva, Nipun L.
Sumanatilleke, Manilka
Somasundaram, Noel P.
Matthews, David R.
author_facet Katulanda, Prasad
Dissanayake, Harsha A.
Ranathunga, Ishara
Ratnasamy, Vithiya
Wijewickrama, Piyumi S. A.
Yogendranathan, Nilukshana
Gamage, Kavinga K. K.
de Silva, Nipun L.
Sumanatilleke, Manilka
Somasundaram, Noel P.
Matthews, David R.
author_sort Katulanda, Prasad
collection PubMed
description The coronavirus disease 2019 (COVID-19) pandemic has emerged as one of the greatest challenges faced by humankind in the recent past. People with diabetes and related comorbidities are at increased risk of its complications and of COVID-19-related death. Older age, multi-morbidity, hyperglycaemia, cardiac injury and severe inflammatory response are predictors of poor outcome. The complex interplay between COVID-19, diabetes and the effects of related therapies is being explored. Most patients experience a mild illness with COVID-19, while people with diabetes are at increased risk of severe disease. Optimising glycaemic control and adopting measures to prevent disease spread are critical aspects. The management of mild disease is supportive, while very many immunomodulatory and antiviral therapies are being investigated for the treatment of severe disease. Several of these agents have specific considerations for use in people with diabetes. Since mass population lockdowns are considered a key step in controlling disease spread, it follows that, in addition to the direct vulnerability to severe COVID-19, people with diabetes can be affected by limited access to healthcare, insulin, other medications and blood glucose monitoring equipment. Measures to prevent disease spread at the individual and community level are the key to mitigating the rapidly escalating pandemic, while agents for chemoprophylaxis and vaccines are being explored. People with diabetes should be recognised as a vulnerable group for complicated disease and are at risk during times of disturbed social systems. Strategies are needed to safeguard the health of patients with diabetes during the pandemic. This review summarises the current knowledge and perceived challenges for prevention and management of COVID-19 in people with diabetes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00125-020-05164-x) contains peer-reviewed but unedited supplementary material including a slideset of the figures for download, which is available to authorised users.
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spelling pubmed-72208502020-05-14 Prevention and management of COVID-19 among patients with diabetes: an appraisal of the literature Katulanda, Prasad Dissanayake, Harsha A. Ranathunga, Ishara Ratnasamy, Vithiya Wijewickrama, Piyumi S. A. Yogendranathan, Nilukshana Gamage, Kavinga K. K. de Silva, Nipun L. Sumanatilleke, Manilka Somasundaram, Noel P. Matthews, David R. Diabetologia Review The coronavirus disease 2019 (COVID-19) pandemic has emerged as one of the greatest challenges faced by humankind in the recent past. People with diabetes and related comorbidities are at increased risk of its complications and of COVID-19-related death. Older age, multi-morbidity, hyperglycaemia, cardiac injury and severe inflammatory response are predictors of poor outcome. The complex interplay between COVID-19, diabetes and the effects of related therapies is being explored. Most patients experience a mild illness with COVID-19, while people with diabetes are at increased risk of severe disease. Optimising glycaemic control and adopting measures to prevent disease spread are critical aspects. The management of mild disease is supportive, while very many immunomodulatory and antiviral therapies are being investigated for the treatment of severe disease. Several of these agents have specific considerations for use in people with diabetes. Since mass population lockdowns are considered a key step in controlling disease spread, it follows that, in addition to the direct vulnerability to severe COVID-19, people with diabetes can be affected by limited access to healthcare, insulin, other medications and blood glucose monitoring equipment. Measures to prevent disease spread at the individual and community level are the key to mitigating the rapidly escalating pandemic, while agents for chemoprophylaxis and vaccines are being explored. People with diabetes should be recognised as a vulnerable group for complicated disease and are at risk during times of disturbed social systems. Strategies are needed to safeguard the health of patients with diabetes during the pandemic. This review summarises the current knowledge and perceived challenges for prevention and management of COVID-19 in people with diabetes. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00125-020-05164-x) contains peer-reviewed but unedited supplementary material including a slideset of the figures for download, which is available to authorised users. Springer Berlin Heidelberg 2020-05-14 2020 /pmc/articles/PMC7220850/ /pubmed/32405783 http://dx.doi.org/10.1007/s00125-020-05164-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Katulanda, Prasad
Dissanayake, Harsha A.
Ranathunga, Ishara
Ratnasamy, Vithiya
Wijewickrama, Piyumi S. A.
Yogendranathan, Nilukshana
Gamage, Kavinga K. K.
de Silva, Nipun L.
Sumanatilleke, Manilka
Somasundaram, Noel P.
Matthews, David R.
Prevention and management of COVID-19 among patients with diabetes: an appraisal of the literature
title Prevention and management of COVID-19 among patients with diabetes: an appraisal of the literature
title_full Prevention and management of COVID-19 among patients with diabetes: an appraisal of the literature
title_fullStr Prevention and management of COVID-19 among patients with diabetes: an appraisal of the literature
title_full_unstemmed Prevention and management of COVID-19 among patients with diabetes: an appraisal of the literature
title_short Prevention and management of COVID-19 among patients with diabetes: an appraisal of the literature
title_sort prevention and management of covid-19 among patients with diabetes: an appraisal of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220850/
https://www.ncbi.nlm.nih.gov/pubmed/32405783
http://dx.doi.org/10.1007/s00125-020-05164-x
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