Altered Brain Endothelial Cell Phenotype from a Familial Alzheimer Mutation and Its Potential Implications for Amyloid Clearance and Drug Delivery

The blood-brain barrier (BBB) presents a barrier for circulating factors, but simultaneously challenges drug delivery. How the BBB is altered in Alzheimer disease (AD) is not fully understood. To facilitate this analysis, we derived brain endothelial cells (iBECs) from human induced pluripotent stem...

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Detalles Bibliográficos
Autores principales: Oikari, Lotta E., Pandit, Rucha, Stewart, Romal, Cuní-López, Carla, Quek, Hazel, Sutharsan, Ratneswary, Rantanen, Laura M., Oksanen, Minna, Lehtonen, Sarka, de Boer, Carmela Maria, Polo, Jose M., Götz, Jürgen, Koistinaho, Jari, White, Anthony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220857/
https://www.ncbi.nlm.nih.gov/pubmed/32275861
http://dx.doi.org/10.1016/j.stemcr.2020.03.011

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