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Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study

PURPOSE: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological p...

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Autores principales: Gómez-Acebo, Inés, Dierssen-Sotos, Trinidad, Palazuelos-Calderón, Camilo, Pérez-Gómez, Beatriz, Amiano, Pilar, Guevara, Marcela, Molina, Antonio J., Domingo, Laia, Fernández-Ortiz, María, Moreno, Victor, Alguacil, Juan, Fernández-Tardón, Guillermo, Ibáñez, Josefa, Marcos-Gragera, Rafael, Diaz-Santos, Marian, Alonso, M. Henar, Alonso-Molero, Jessica, Castaño-Vinyals, Gemma, Palomo, Andrés García, Ardanaz, Eva, Molinuevo, Amaia, Aragonés, Nuria, Kogevinas, Manolis, Pollán, Marina, Llorca, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220874/
https://www.ncbi.nlm.nih.gov/pubmed/32356254
http://dx.doi.org/10.1007/s10549-020-05600-x
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author Gómez-Acebo, Inés
Dierssen-Sotos, Trinidad
Palazuelos-Calderón, Camilo
Pérez-Gómez, Beatriz
Amiano, Pilar
Guevara, Marcela
Molina, Antonio J.
Domingo, Laia
Fernández-Ortiz, María
Moreno, Victor
Alguacil, Juan
Fernández-Tardón, Guillermo
Ibáñez, Josefa
Marcos-Gragera, Rafael
Diaz-Santos, Marian
Alonso, M. Henar
Alonso-Molero, Jessica
Castaño-Vinyals, Gemma
Palomo, Andrés García
Ardanaz, Eva
Molinuevo, Amaia
Aragonés, Nuria
Kogevinas, Manolis
Pollán, Marina
Llorca, Javier
author_facet Gómez-Acebo, Inés
Dierssen-Sotos, Trinidad
Palazuelos-Calderón, Camilo
Pérez-Gómez, Beatriz
Amiano, Pilar
Guevara, Marcela
Molina, Antonio J.
Domingo, Laia
Fernández-Ortiz, María
Moreno, Victor
Alguacil, Juan
Fernández-Tardón, Guillermo
Ibáñez, Josefa
Marcos-Gragera, Rafael
Diaz-Santos, Marian
Alonso, M. Henar
Alonso-Molero, Jessica
Castaño-Vinyals, Gemma
Palomo, Andrés García
Ardanaz, Eva
Molinuevo, Amaia
Aragonés, Nuria
Kogevinas, Manolis
Pollán, Marina
Llorca, Javier
author_sort Gómez-Acebo, Inés
collection PubMed
description PURPOSE: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. METHODS: The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. RESULTS: Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. CONCLUSION: Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10549-020-05600-x) contains supplementary material, which is available to authorised users.
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spelling pubmed-72208742020-05-14 Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study Gómez-Acebo, Inés Dierssen-Sotos, Trinidad Palazuelos-Calderón, Camilo Pérez-Gómez, Beatriz Amiano, Pilar Guevara, Marcela Molina, Antonio J. Domingo, Laia Fernández-Ortiz, María Moreno, Victor Alguacil, Juan Fernández-Tardón, Guillermo Ibáñez, Josefa Marcos-Gragera, Rafael Diaz-Santos, Marian Alonso, M. Henar Alonso-Molero, Jessica Castaño-Vinyals, Gemma Palomo, Andrés García Ardanaz, Eva Molinuevo, Amaia Aragonés, Nuria Kogevinas, Manolis Pollán, Marina Llorca, Javier Breast Cancer Res Treat Epidemiology PURPOSE: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. METHODS: The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. RESULTS: Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. CONCLUSION: Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10549-020-05600-x) contains supplementary material, which is available to authorised users. Springer US 2020-04-30 2020 /pmc/articles/PMC7220874/ /pubmed/32356254 http://dx.doi.org/10.1007/s10549-020-05600-x Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Gómez-Acebo, Inés
Dierssen-Sotos, Trinidad
Palazuelos-Calderón, Camilo
Pérez-Gómez, Beatriz
Amiano, Pilar
Guevara, Marcela
Molina, Antonio J.
Domingo, Laia
Fernández-Ortiz, María
Moreno, Victor
Alguacil, Juan
Fernández-Tardón, Guillermo
Ibáñez, Josefa
Marcos-Gragera, Rafael
Diaz-Santos, Marian
Alonso, M. Henar
Alonso-Molero, Jessica
Castaño-Vinyals, Gemma
Palomo, Andrés García
Ardanaz, Eva
Molinuevo, Amaia
Aragonés, Nuria
Kogevinas, Manolis
Pollán, Marina
Llorca, Javier
Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_full Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_fullStr Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_full_unstemmed Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_short Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study
title_sort tumour characteristics and survivorship in a cohort of breast cancer: the mcc-spain study
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220874/
https://www.ncbi.nlm.nih.gov/pubmed/32356254
http://dx.doi.org/10.1007/s10549-020-05600-x
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