Cargando…

The early local and systemic Type I interferon responses to ultraviolet B light exposure are cGAS dependent

Most systemic lupus erythematosus (SLE) patients are photosensitive and ultraviolet B light (UVB) exposure worsens cutaneous disease and precipitates systemic flares of disease. The pathogenic link between skin disease and systemic exacerbations in SLE remains elusive. In an acute model of UVB-trigg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Skopelja-Gardner, Sladjana, An, Jie, Tai, Joyce, Tanaka, Lena, Sun, Xizhang, Hermanson, Payton, Baum, Rebecca, Kawasumi, Masaoki, Green, Richard, Gale Jr., Michael, Kalus, Andrea, Werth, Victoria P., Elkon, Keith B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220927/ https://www.ncbi.nlm.nih.gov/pubmed/32404939 http://dx.doi.org/10.1038/s41598-020-64865-w

Ejemplares similares

Role of the cGAS–STING pathway in systemic and organ-specific diseases
por: Skopelja-Gardner, Sladjana, et al.
Publicado: (2022)

Chikungunya virus antagonizes cGAS-STING mediated type-I interferon responses by degrading cGAS
por: Webb, L. G., et al.
Publicado: (2020)

Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression
por: Fu, Yajuan, et al.
Publicado: (2020)

Killing three birds with one BPI: Bactericidal, opsonic, and anti-inflammatory functions
por: Theprungsirikul, Jomkuan, et al.
Publicado: (2021)

cGAS- Stimulator of Interferon Genes Signaling in Central Nervous System Disorders
por: Li, Fengjuan, et al.
Publicado: (2021)

Perillaldehyde Inhibition of cGAS Reduces dsDNA-Induced Interferon Response
por: Chu, Lei, et al.
Publicado: (2021)

Grouper cGAS is a negative regulator of STING-mediated interferon response
por: Zhang, Luhao, et al.
Publicado: (2023)

The Regulation of cGAS
por: Xiong, Meiguang, et al.
Publicado: (2018)

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability
por: Hong, Christy, et al.
Publicado: (2019)

Enhanced cGAS-STING–dependent interferon signaling associated with mutations in ATAD3A
por: Lepelley, Alice, et al.
Publicado: (2021)

PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS‐STING‐Mediated Interferon Response
por: Geng, Xinwei, et al.
Publicado: (2022)

Crosstalk Between Autophagy and the cGAS–STING Signaling Pathway in Type I Interferon Production
por: Zhang, Kunli, et al.
Publicado: (2021)

The multifaceted functions of cGAS
por: Liu, Haipeng, et al.
Publicado: (2022)

Bactericidal/Permeability-Increasing Protein Preeminently Mediates Clearance of Pseudomonas aeruginosa In Vivo via CD18-Dependent Phagocytosis
por: Theprungsirikul, Jomkuan, et al.
Publicado: (2021)

Immune complex–driven neutrophil activation and BAFF release: a link to B cell responses in SLE
por: Wang, Ting, et al.
Publicado: (2022)

Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice
por: Vincent, Jessica, et al.
Publicado: (2017)

Cutibacterium acnes Infection Induces Type I Interferon Synthesis Through the cGAS-STING Pathway
por: Fischer, Katrin, et al.
Publicado: (2020)

Traumatic Brain Injury Induces cGAS Activation and Type I Interferon Signaling in Aged Mice
por: Barrett, James P., et al.
Publicado: (2021)

Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury
por: Fritsch, Lauren E., et al.
Publicado: (2022)

The Chicken cGAS–STING Pathway Exerts Interferon-Independent Antiviral Function via Cell Apoptosis
por: Jiang, Sen, et al.
Publicado: (2023)

The many faces of cGAS: how cGAS activation is controlled in the cytosol, the nucleus, and during mitosis
por: Herzner, Anna-Maria, et al.
Publicado: (2021)

Nuclear cGAS: guard or prisoner?
por: de Oliveira Mann, Carina C, et al.
Publicado: (2021)

Nuclear cGAS: sequestration and beyond
por: Bai, Juli, et al.
Publicado: (2021)

cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells
por: Paijo, Jennifer, et al.
Publicado: (2016)

STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection
por: Ding, Siyuan, et al.
Publicado: (2018)

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression
por: Lama, Lodoe, et al.
Publicado: (2019)

Autoimmunity gene IRGM suppresses cGAS‐STING and RIG‐I‐MAVS signaling to control interferon response
por: Jena, Kautilya Kumar, et al.
Publicado: (2020)

Priming of the cGAS-STING-TBK1 Pathway Enhances LPS-Induced Release of Type I Interferons
por: Tesser, Alessandra, et al.
Publicado: (2021)

Commentary: Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury
por: McEntee, Cali M., et al.
Publicado: (2022)

Corrigendum: Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury
por: Fritsch, Lauren E., et al.
Publicado: (2022)

Publisher Correction: Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice
por: Vincent, Jessica, et al.
Publicado: (2017)

PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection
por: Wang, Zhenyu, et al.
Publicado: (2021)

Chronic exposure to Cytolethal Distending Toxin (CDT) promotes a cGAS-dependent type I interferon response
por: Pons, Benoît J., et al.
Publicado: (2021)

Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice
por: Skopelja-Gardner, Sladjana, et al.
Publicado: (2017)

cGAS-STING pathway in cancer biotherapy
por: Wang, Yang, et al.
Publicado: (2020)

Pharmacological Activation of cGAS for Cancer Immunotherapy
por: Garland, Kyle M., et al.
Publicado: (2021)

Regulation of cGAS Activity and Downstream Signaling
por: Joshi, Bhagwati, et al.
Publicado: (2022)

HSP27 Attenuates cGAS-Mediated IFN-β Signaling through Ubiquitination of cGAS and Promotes PRV Infection
por: Li, Xiangrong, et al.
Publicado: (2022)

SV40 Large T Antigen Is Not Responsible for the Loss of STING in 293T Cells but Can Inhibit cGAS-STING Interferon Induction
por: Reus, Joshua B., et al.
Publicado: (2020)

The cGAS/STING–TBK1–IRF Regulatory Axis Orchestrates a Primitive Interferon-Like Antiviral Mechanism in Oyster
por: Qiao, Xue, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_d432ltapgiurpj95fhuh895qlp