TGFβ Signaling Increases Net Acid Extrusion, Proliferation and Invasion in Panc-1 Pancreatic Cancer Cells: SMAD4 Dependence and Link to Merlin/NF2 Signaling

Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related death, with a 5-year survival of <10% and severely limited treatment options. PDAC hallmarks include profound metabolic acid production and aggressive local proliferation and invasiveness. This phenotype is supported by up...

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Detalles Bibliográficos
Autores principales: Malinda, Raj R., Zeeberg, Katrine, Sharku, Patricia C., Ludwig, Mette Q., Pedersen, Lotte B., Christensen, Søren T., Pedersen, Stine F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221161/
https://www.ncbi.nlm.nih.gov/pubmed/32457840
http://dx.doi.org/10.3389/fonc.2020.00687

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