Cargando…

Iron protects childhood acute lymphoblastic leukemia cells from methotrexate cytotoxicity

Drug resistance is a fundamental clinical concern in pediatric acute lymphoblastic leukemia (pALL), and methotrexate (MTX) is an essential chemotherapy drug administered for the treatment. In the current study, the effect of iron in response to methotrexate and its underlying mechanisms were investi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abedi, Marjan, Rahgozar, Soheila, Esmaeili, Abolghasem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221302/ https://www.ncbi.nlm.nih.gov/pubmed/32176452 http://dx.doi.org/10.1002/cam4.2982

Ejemplares similares

The relationship between iron bone marrow stores and response to treatment in pediatric acute lymphoblastic leukemia
por: Moafi, Alireza, et al.
Publicado: (2017)

The effects of Astragalus polysaccharides, tragacanthin, and bassorin on methotrexate-resistant acute lymphoblastic leukemia
por: Samii, Bahareh, et al.
Publicado: (2023)

Drug Resistance Biomarkers and Their Clinical Applications in Childhood Acute Lymphoblastic Leukemia
por: Aberuyi, Narges, et al.
Publicado: (2020)

Iron oxide nanoparticles may damage to the neural tissue through iron accumulation, oxidative stress, and protein aggregation
por: Yarjanli, Zahra, et al.
Publicado: (2017)

Quercetin-Conjugated Superparamagnetic Iron Oxide Nanoparticles Protect AlCl(3)-Induced Neurotoxicity in a Rat Model of Alzheimer’s Disease via Antioxidant Genes, APP Gene, and miRNA-101
por: Amanzadeh Jajin, Elnaz, et al.
Publicado: (2021)

The genomic landscape of teenage and young adult T‐cell acute lymphoblastic leukemia
por: Mansur, Marcela B., et al.
Publicado: (2021)

A genetic variant in miR‐100 is a protective factor of childhood acute lymphoblastic leukemia
por: Xue, Yao, et al.
Publicado: (2019)

Resistance of t(17;19)‐acute lymphoblastic leukemia cell lines to multiagents in induction therapy
por: Watanabe, Atsushi, et al.
Publicado: (2019)

Mutational profiling in acute lymphoblastic leukemia by RNA sequencing and chromosomal genomic array testing
por: Yeung, Cecilia, et al.
Publicado: (2021)

Methotrexate resistance in relation to treatment outcome in childhood acute lymphoblastic leukemia
por: Wojtuszkiewicz, Anna, et al.
Publicado: (2015)

MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy
por: Umerez, Maitane, et al.
Publicado: (2017)

High-dose methotrexate vs. Capizzi methotrexate for the treatment of childhood T-cell acute lymphoblastic leukemia
por: Jastaniah, Wasil, et al.
Publicado: (2018)

miR-16-5p enhances sensitivity to RG7388 through targeting PPM1D expression (WIP1) in Childhood Acute Lymphoblastic Leukemia
por: Zanjirband, Maryam, et al.
Publicado: (2023)

Integrated bioinformatics analysis of the crucial candidate genes and pathways associated with glucocorticoid resistance in acute lymphoblastic leukemia
por: Chen, Yanxin, et al.
Publicado: (2020)

The antitoxic effects of quercetin and quercetin-conjugated iron oxide nanoparticles (QNPs) against H(2)O(2)-induced toxicity in PC12 cells
por: Yarjanli, Zahra, et al.
Publicado: (2019)

Epigenetic Priming in Childhood Acute Lymphoblastic Leukemia
por: Raboso-Gallego, Javier, et al.
Publicado: (2019)

Living on a farm, contact with farm animals and pets, and childhood acute lymphoblastic leukemia: pooled and meta‐analyses from the Childhood Leukemia International Consortium
por: Orsi, Laurent, et al.
Publicado: (2018)

LINC00221 suppresses the malignancy of children acute lymphoblastic leukemia
por: Huang, Man, et al.
Publicado: (2020)

The role of ATP-binding cassette transporter A2 in childhood acute lymphoblastic leukemia multidrug resistance
por: Aberuyi, N, et al.
Publicado: (2014)

Mercaptopurine/Methotrexate Maintenance Therapy of Childhood Acute Lymphoblastic Leukemia: Clinical Facts and Fiction
por: Schmiegelow, Kjeld, et al.
Publicado: (2014)

Clofarabine exerts antileukemic activity against cytarabine‐resistant B‐cell precursor acute lymphoblastic leukemia with low deoxycytidine kinase expression
por: Huang, Meixian, et al.
Publicado: (2018)

An integrated transcriptome analysis in T‐cell acute lymphoblastic leukemia links DNA methylation subgroups to dysregulated TAL1 and ANTP homeobox gene expression
por: Haider, Zahra, et al.
Publicado: (2018)

RAG1 co‐expression signature identifies ETV6‐RUNX1‐like B‐cell precursor acute lymphoblastic leukemia in children
por: Chen, Dongfeng, et al.
Publicado: (2021)

The Hedgehog signal transducer Smoothened and microRNA-326: pathogenesis and regulation of drug resistance in pediatric B-cell acute lymphoblastic leukemia
por: Sheybani, Zahra, et al.
Publicado: (2019)

A convergent malignant phenotype in B-cell acute lymphoblastic leukemia involving the splicing factor SRRM1
por: Closa, Adria, et al.
Publicado: (2022)

Case report: Intravitreal methotrexate in intraocular acute lymphoblastic leukemia
por: Pederzolli, Matteo, et al.
Publicado: (2022)

Methotrexate-Mediated Arachnoiditis in a Child with Acute Lymphoblastic Leukemia
por: Karamercan, Sırma, et al.
Publicado: (2022)

Glutamic Acid Increased Methotrexate Polyglutamation and Cytotoxicity in a CCRF-SB Acute Lymphoblastic Leukemia Cell Line
por: Mendoza-Santiago, Alma, et al.
Publicado: (2019)

Data for the measurement of serum vitamin D metabolites in childhood acute lymphoblastic leukemia survivors
por: Delvin, E., et al.
Publicado: (2018)

The Clinicogenomic Landscape of Induction Failure in Childhood and Young Adult T-Cell Acute Lymphoblastic Leukemia
por: O'Connor, David, et al.
Publicado: (2023)

Septicemia after chemotherapy for childhood acute lymphoblastic leukemia in China: A multicenter study CCCG‐ALL‐2015
por: Zhu, Yiping, et al.
Publicado: (2020)

Intracranial Hemorrhage Following Oral Low-Dose Methotrexate After Multiple Toxicities Caused by High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia
por: Xin, Ning, et al.
Publicado: (2019)

Mechanism of circADD2 as ceRNA in Childhood Acute Lymphoblastic Leukemia
por: Zhu, Yuting, et al.
Publicado: (2021)

The evaluation of red blood cell folate and methotrexate levels during protocol M in childhood acute lymphoblastic leukemia
por: Oosterom, N., et al.
Publicado: (2020)

The Microbiome in Childhood Acute Lymphoblastic Leukemia
por: Oldenburg, Marina, et al.
Publicado: (2021)

The translational expression of ABCA2 and ABCA3 is a strong prognostic biomarker for multidrug resistance in pediatric acute lymphoblastic leukemia
por: Aberuyi, Narges, et al.
Publicado: (2017)

Fatty acid synthase, a novel poor prognostic factor for acute lymphoblastic leukemia which can be targeted by ginger extract
por: Ghaeidamini, Maryam Harouni, et al.
Publicado: (2020)

Methotrexate-induced chemical meningitis in patients with acute lymphoblastic leukemia/lymphoma
por: Jacob, Linu A., et al.
Publicado: (2015)

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia
por: García-Cañaveras, Juan C., et al.
Publicado: (2020)

Nutritional Interventions in Pediatric Patients With Acute Lymphoblastic Leukemia: A Systematic Review
por: León, Alan Guzmán, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8m07kn07tcr7alf0va55rorr4l