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TIGIT enhances CD4(+) regulatory T‐cell response and mediates immune suppression in a murine ovarian cancer model

Ovarian cancer (OC) is the fifth‐leading cause of cancer‐related death in women with a pathogenesis involving activation of regulatory T cells (Tregs). The T‐cell immunoglobulin and ITIM domain (TIGIT) is a well‐known immune checkpoint molecule that inhibits T‐cell responses. However, the role of TI...

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Detalles Bibliográficos
Autores principales:	Chen, Fengzhen, Xu, Yanying, Chen, Yulong, Shan, Shu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221438/ https://www.ncbi.nlm.nih.gov/pubmed/32212317 http://dx.doi.org/10.1002/cam4.2976

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