First Example of Catalytic Synthesis of Cyclic S-Containing Di- and Triperoxides

An efficient method for the synthesis of tetraoxathiaspiroalkanes, tetraoxathiocanes, and hexaoxathiadispiroalkanes was developed by reactions of pentaoxacanes, pentaoxaspiroalkanes, and heptaoxadispiroalkanes with hydrogen sulfide in the presence of a catalyst, Sm(NO(3))(3)·6H(2)O. We found that th...

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Detalles Bibliográficos
Autores principales: Makhmudiyarova, Nataliya, Ishmukhametova, Irina, Dzhemileva, Lilya, D’yakonov, Vladimir, Ibragimov, Askhat, Dzhemilev, Usein
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221664/
https://www.ncbi.nlm.nih.gov/pubmed/32325665
http://dx.doi.org/10.3390/molecules25081874
Descripción
Sumario:An efficient method for the synthesis of tetraoxathiaspiroalkanes, tetraoxathiocanes, and hexaoxathiadispiroalkanes was developed by reactions of pentaoxacanes, pentaoxaspiroalkanes, and heptaoxadispiroalkanes with hydrogen sulfide in the presence of a catalyst, Sm(NO(3))(3)·6H(2)O. We found that the synthesized S-containing di- and triperoxides exhibit high cytotoxic activity against Jurkat, K562, U937, and HL60 tumor cultures, and fibroblasts.

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