Three-Component Access to Functionalized Spiropyrrolidine Heterocyclic Scaffolds and Their Cholinesterase Inhibitory Activity

A novel one-pot [3+2]-cycloaddition reaction of (E)-3-arylidene-1-phenyl-succinimides, cyclic 1,2-diketones (isatin, 5-chloro-isatin and acenaphtenequinone), and diverse α-aminoacids such as 2-phenylglycine or sarcosine is reported. The reaction provides succinimide-substituted dispiropyrrolidine de...

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Detalles Bibliográficos
Autores principales: Boudriga, Sarra, Haddad, Saoussen, Murugaiyah, Vikneswaran, Askri, Moheddine, Knorr, Michael, Strohmann, Carsten, Golz, Christopher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221748/
https://www.ncbi.nlm.nih.gov/pubmed/32340203
http://dx.doi.org/10.3390/molecules25081963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221748/
https://www.ncbi.nlm.nih.gov/pubmed/32340203
http://dx.doi.org/10.3390/molecules25081963

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