Cargando…

Transcriptomics in Toxicogenomics, Part I: Experimental Design, Technologies, Publicly Available Data, and Regulatory Aspects

The starting point of successful hazard assessment is the generation of unbiased and trustworthy data. Conventional toxicity testing deals with extensive observations of phenotypic endpoints in vivo and complementing in vitro models. The increasing development of novel materials and chemical compoun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kinaret, Pia Anneli Sofia, Serra, Angela, Federico, Antonio, Kohonen, Pekka, Nymark, Penny, Liampa, Irene, Ha, My Kieu, Choi, Jang-Sik, Jagiello, Karolina, Sanabria, Natasha, Melagraki, Georgia, Cattelani, Luca, Fratello, Michele, Sarimveis, Haralambos, Afantitis, Antreas, Yoon, Tae-Hyun, Gulumian, Mary, Grafström, Roland, Puzyn, Tomasz, Greco, Dario
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221878/ https://www.ncbi.nlm.nih.gov/pubmed/32326418 http://dx.doi.org/10.3390/nano10040750

Ejemplares similares

Transcriptomics in Toxicogenomics, Part III: Data Modelling for Risk Assessment
por: Serra, Angela, et al.
Publicado: (2020)

Transcriptomics in Toxicogenomics, Part II: Preprocessing and Differential Expression Analysis for High Quality Data
por: Federico, Antonio, et al.
Publicado: (2020)

Read-across predictions of nanoparticle hazard endpoints: a mathematical optimization approach
por: Varsou, Dimitra-Danai, et al.
Publicado: (2019)

Nextcast: A software suite to analyse and model toxicogenomics data
por: Serra, Angela, et al.
Publicado: (2022)

Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials
por: Saarimäki, Laura Aliisa, et al.
Publicado: (2021)

Can an InChI for Nano Address the Need for a Simplified Representation of Complex Nanomaterials across Experimental and Nanoinformatics Studies?
por: Lynch, Iseult, et al.
Publicado: (2020)

A safe-by-design tool for functionalised nanomaterials through the Enalos Nanoinformatics Cloud platform
por: Varsou, Dimitra-Danai, et al.
Publicado: (2018)

Importance of Surface Topography in Both Biological Activity and Catalysis of Nanomaterials: Can Catalysis by Design Guide Safe by Design?
por: Gulumian, Mary, et al.
Publicado: (2021)

An ancestral molecular response to nanomaterial particulates
por: del Giudice, G., et al.
Publicado: (2023)

Advances in De Novo Drug Design: From Conventional to Machine Learning Methods
por: Mouchlis, Varnavas D., et al.
Publicado: (2021)

Methods, models, mechanisms and metadata: Introducing the Nanotoxicology collection at F1000Research
por: Lynch, Iseult, et al.
Publicado: (2021)

NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment
por: Afantitis, Antreas, et al.
Publicado: (2020)

Open Source Chemoinformatics Software including KNIME Analytics
por: Leonis, Georgios, et al.
Publicado: (2016)

TinderMIX: Time-dose integrated modelling of toxicogenomics data
por: Serra, Angela, et al.
Publicado: (2020)

Editorial for the Special Issue From Nanoinformatics to Nanomaterials Risk Assessment and Governance
por: Lynch, Iseult, et al.
Publicado: (2021)

Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer’s Therapeutics
por: Mouchlis, Varnavas D., et al.
Publicado: (2020)

In Silico Identification and Evaluation of Natural Products as Potential Tumor Necrosis Factor Function Inhibitors Using Advanced Enalos Asclepios KNIME Nodes
por: Papadopoulou, Dimitra, et al.
Publicado: (2021)

Toxicogenomics Data for Chemical Safety Assessment and Development of New Approach Methodologies: An Adverse Outcome Pathway‐Based Approach
por: Saarimäki, Laura Aliisa, et al.
Publicado: (2022)

A Systematic Review of Deep Learning Methodologies Used in the Drug Discovery Process with Emphasis on In Vivo Validation
por: Koutroumpa, Nikoletta-Maria, et al.
Publicado: (2023)

Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways
por: Kinaret, Pia A. S., et al.
Publicado: (2021)

ESPERANTO: a GLP-field sEmi-SuPERvised toxicogenomics metadAta curatioN TOol
por: Di Lieto, Emanuele, et al.
Publicado: (2023)

Exploring the Binding Effects of Natural Products and Antihypertensive Drugs on SARS-CoV-2: An In Silico Investigation of Main Protease and Spike Protein
por: Moschovou, Kalliopi, et al.
Publicado: (2023)

European Registry of Materials: global, unique identifiers for (undisclosed) nanomaterials
por: van Rijn, Jeaphianne, et al.
Publicado: (2022)

In Silico Discovery of Plant-Origin Natural Product Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)
por: Melagraki, Georgia, et al.
Publicado: (2018)

Predicting Cytotoxicity of Metal Oxide Nanoparticles Using Isalos Analytics Platform
por: Papadiamantis, Anastasios G., et al.
Publicado: (2020)

Functionalized 4-Hydroxy Coumarins: Novel Synthesis, Crystal Structure and DFT Calculations
por: Stefanou, Valentina, et al.
Publicado: (2011)

Structure-Based Discovery of Novel Chemical Classes of Autotaxin Inhibitors
por: Magkrioti, Christiana, et al.
Publicado: (2020)

Enalos KNIME nodes: exploring environmental durability, ageing resistance and corrosion inhibition
por: Tsoumanis, A, et al.
Publicado: (2013)

Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)
por: Melagraki, Georgia, et al.
Publicado: (2017)

Development of artificial neural network models to predict the PAMPA effective permeability of new, orally administered drugs active against the coronavirus SARS-CoV-2
por: Gousiadou, Chrysoula, et al.
Publicado: (2023)

An introduction to toxicogenomics /
Publicado: (2003)

EHP Toxicogenomics
por: Dooley, E
Publicado: (2002)

The eNanoMapper database for nanomaterial safety information
por: Jeliazkova, Nina, et al.
Publicado: (2015)

Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation
por: Serra, Angela, et al.
Publicado: (2021)

QSAR modeling of the toxicity classification of superparamagnetic iron oxide nanoparticles (SPIONs) in stem-cell monitoring applications: an integrated study from data curation to model development
por: Kotzabasaki, Marianna I., et al.
Publicado: (2020)

Handbook of toxicogenomics : strategies and applications. /
Publicado: (2005)

Standardization Initiatives in the (eco)toxicogenomics Domain: A Review
por: Sansone, Susanna Assunta, et al.
Publicado: (2004)

An In Vitro Dosimetry Tool for the Numerical Transport Modeling of Engineered Nanomaterials Powered by the Enalos RiskGONE Cloud Platform
por: Cheimarios, Nikolaos, et al.
Publicado: (2022)

Toxicogenomics: Principles and Applications
por: Omenn, Gilbert S.
Publicado: (2004)

Toxicogenomics: an emerging discipline.
por: Schmidt, Charles W
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_3qlvl3p1hdh09e17cvroa8tdfc