Cargando…

Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening

Neurodegenerative diseases represent a significant unmet medical need in our aging society. There are no effective treatments for most of these diseases, and we know comparatively little regarding pathogenic mechanisms. Among the challenges faced by those involved in developing therapeutic drugs for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chang, Chia-Yu, Ting, Hsiao-Chien, Liu, Ching-Ann, Su, Hong-Lin, Chiou, Tzyy-Wen, Lin, Shinn-Zong, Harn, Horng-Jyh, Ho, Tsung-Jung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221979/ https://www.ncbi.nlm.nih.gov/pubmed/32344649 http://dx.doi.org/10.3390/molecules25082000

Ejemplares similares

Induced Pluripotent Stem Cells: A Powerful Neurodegenerative Disease Modeling Tool for Mechanism Study and Drug Discovery
por: Chang, Chia-Yu, et al.
Publicado: (2018)

Differentiation of Human Pluripotent Stem Cells Into Specific Neural Lineages
por: Chang, Chia-Yu, et al.
Publicado: (2021)

Robust Generation of Ready-to-Use Cryopreserved Motor Neurons from Human Pluripotent Stem Cells for Disease Modeling
por: Ting, Hsiao-Chien, et al.
Publicado: (2022)

Advances in Patient-Specific Induced Pluripotent Stem Cells Shed Light on Drug Discovery for Amyotrophic Lateral Sclerosis
por: Lee, Jui-Hao, et al.
Publicado: (2018)

Chinese herbs and acupuncture to improve cognitive function in Alzheimer's disease
por: WuLi, Wei, et al.
Publicado: (2021)

Migration/Invasion of Malignant Gliomas and Implications for Therapeutic Treatment
por: Liu, Ching-Ann, et al.
Publicado: (2018)

The Role of Gene Editing in Neurodegenerative Diseases
por: Fan, Hueng-Chuen, et al.
Publicado: (2018)

iPSC‐based modeling of THD recapitulates disease phenotypes and reveals neuronal malformation
por: Tristán‐Noguero, Alba, et al.
Publicado: (2023)

Human-Induced Pluripotent Stem Cells and Herbal Small-Molecule Drugs for Treatment of Alzheimer’s Disease
por: Wuli, Wei, et al.
Publicado: (2020)

iPSC for modeling neurodegenerative disorders
por: Valadez-Barba, Valeria, et al.
Publicado: (2020)

Suspension culture improves iPSC expansion and pluripotency phenotype
por: Cuesta-Gomez, Nerea, et al.
Publicado: (2023)

Effect of Cinnamomum osmophloeum Kanehira Leaf Aqueous Extract on Dermal Papilla Cell Proliferation and Hair Growth
por: Wen, Tung-Chou, et al.
Publicado: (2018)

Interferon-γ signaling in human iPSC–derived neurons recapitulates neurodevelopmental disorder phenotypes
por: Warre-Cornish, Katherine, et al.
Publicado: (2020)

n-Butylidenephthalide Modulates Autophagy to Ameliorate Neuropathological Progress of Spinocerebellar Ataxia Type 3 through mTOR Pathway
por: Lee, Jui-Hao, et al.
Publicado: (2021)

MS‐Driven Metabolic Alterations Are Recapitulated in iPSC‐Derived Astrocytes
por: Ghirotto, Bruno, et al.
Publicado: (2022)

n-Butylidenephthalide Regulated Tumor Stem Cell Genes EZH2/AXL and Reduced Its Migration and Invasion in Glioblastoma
por: Yen, Ssu-Yin, et al.
Publicado: (2017)

Remote transplantation of human adipose-derived stem cells induces regression of cardiac hypertrophy by regulating the macrophage polarization in spontaneously hypertensive rats
por: Lee, Tsung-Ming, et al.
Publicado: (2019)

Host pre‐conditioning improves human adipose–derived stem cell transplantation in ageing rats after myocardial infarction: Role of NLRP3 inflammasome
por: Lee, Tsung‐Ming, et al.
Publicado: (2020)

Isochaihulactone-induced DDIT3 causes ER stress-PERK independent apoptosis in glioblastoma multiforme cells
por: Tsai, Sheng-Feng, et al.
Publicado: (2016)

Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases
por: Fan, Hueng-Chuen, et al.
Publicado: (2015)

Coactivation of GSK3β and IGF-1 Attenuates Amyotrophic Lateral Sclerosis Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons
por: Ting, Hsiao-Chien, et al.
Publicado: (2021)

Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress–mediated hippocampal damage after myocardial infarction
por: LEE, Tsung-Ming, et al.
Publicado: (2021)

The Role of Butylidenephthalide in Targeting the Microenvironment Which Contributes to Liver Fibrosis Amelioration
por: Chuang, Hong-Meng, et al.
Publicado: (2016)

The Role of Biomaterials in Implantation for Central Nervous System Injury
por: Chen, Yu-Shuan, et al.
Publicado: (2018)

Food Supplement 20070721-GX May Increase CD34(+) Stem Cells and Telomerase Activity
por: Lin, Po-Cheng, et al.
Publicado: (2012)

Non-Canonical Regulation of Type I Collagen through Promoter Binding of SOX2 and Its Contribution to Ameliorating Pulmonary Fibrosis by Butylidenephthalide
por: Chuang, Hong-Meng, et al.
Publicado: (2018)

Recapitulation of Human Neural Microenvironment Signatures in iPSC-Derived NPC 3D Differentiation
por: Simão, Daniel, et al.
Publicado: (2018)

Exosomes in clinical trial and their production in compliance with good manufacturing practice
por: Chen, Yu-Shuan, et al.
Publicado: (2019)

N-Butylidenephthalide Inhibits the Phenotypic Switch of VSMCs through Activation of AMPK and Prevents Stenosis in an Arteriovenous Fistula Rat Model
por: Yang, Hsin-Han, et al.
Publicado: (2020)

Human iPSC banking: barriers and opportunities
por: Huang, Ching-Ying, et al.
Publicado: (2019)

Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities
por: Paci, Michelangelo, et al.
Publicado: (2018)

An Alternative Cell Therapy for Cancers: Induced Pluripotent Stem Cell (iPSC)-Derived Natural Killer Cells
por: Hsu, Li-Jie, et al.
Publicado: (2021)

Human Olfactory Ensheathing Cell Transplantation Improves Motor Function in a Mouse Model of Type 3 Spinocerebellar Ataxia
por: Hsieh, Jeanne, et al.
Publicado: (2017)

Targeting the Axl and mTOR Pathway Synergizes Immunotherapy and Chemotherapy to Butylidenephthalide in a Recurrent GBM
por: Liu, Ching-Ann, et al.
Publicado: (2022)

Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models
por: Fernández-Santiago, Rubén, et al.
Publicado: (2016)

Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis
por: Yucer, Nur, et al.
Publicado: (2021)

Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes
por: Verheyen, An, et al.
Publicado: (2018)

Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes
por: Verheyen, An, et al.
Publicado: (2019)

Exosomes and Stem Cells in Degenerative Disease Diagnosis and Therapy
por: Chang, Yu-Hsun, et al.
Publicado: (2018)

Three dimensional collagen scaffolds promote iPSC induction with higher pluripotency
por: Gu, Qi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_eb5mgu7eot67ulh20mda4e0vea