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Synthesis, Docking, and In Vitro Anticoagulant Activity Assay of Hybrid Derivatives of Pyrrolo[3,2,1-ij]Quinolin-2(1H)-one as New Inhibitors of Factor Xa and Factor XIa

Coagulation factor Xa and factor XIa are proven to be convenient and crucial protein targets for treatment for thrombotic disorders and thereby their inhibitors can serve as effective anticoagulant drugs. In the present work, we focused on the structure–activity relationships of derivatives of pyrro...

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Detalles Bibliográficos
Autores principales:	Novichikhina, Nadezhda, Ilin, Ivan, Tashchilova, Anna, Sulimov, Alexey, Kutov, Danil, Ledenyova, Irina, Krysin, Mikhail, Shikhaliev, Khidmet, Gantseva, Anna, Gantseva, Ekaterina, Podoplelova, Nadezhda, Sulimov, Vladimir
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222003/ https://www.ncbi.nlm.nih.gov/pubmed/32325823 http://dx.doi.org/10.3390/molecules25081889

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