Junctional and somatic hypermutation-induced CX(4)C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody

Induction of broadly neutralizing monoclonal antibodies (bNAbs) that bind to the viral envelope glycoproteins is a major goal of hepatitis C virus (HCV) vaccine research. The study of bNAbs arising in natural infection is essential in this endeavor. We generated a human antibody, 8D6, recognizing th...

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Detalles Bibliográficos
Autores principales: Yi, Chunyan, Xia, Jing, He, Lan, Ling, Zhiyang, Wang, Xuesong, Yan, Yu, Wang, Jiangjun, Zhao, Xinhao, Fan, Weiguo, Sun, Xiaoyu, Zhang, Ronghua, Ye, Sheng, Zhang, Rongguang, Xu, Yongfen, Ma, Liyan, Zhang, Yaguang, Zhou, Honglin, Huang, Zhong, Niu, Junqi, Long, Gang, Lu, Junxia, Zhong, Jin, Sun, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222171/
https://www.ncbi.nlm.nih.gov/pubmed/32235917
http://dx.doi.org/10.1038/s41423-020-0403-1

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