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Maternal Antioxidant Status in Early Pregnancy and Development of Fetal Complications in Twin Pregnancies: A Pilot Study

Twin pregnancies are increasing due to the rise in mothers’ childbearing age and have a higher risk of fetal growth restriction (FGR) and prematurity. Therefore, early prediction of these events is important. Our aim was to analyze in the first trimester of pregnancy a possible association between a...

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Autores principales: Ramiro-Cortijo, David, de la Calle, María, Rodríguez-Rodríguez, Pilar, López de Pablo, Ángel L., López-Giménez, María R., Aguilera, Yolanda, Martín-Cabrejas, María A., González, María del Carmen, Arribas, Silvia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222178/
https://www.ncbi.nlm.nih.gov/pubmed/32218124
http://dx.doi.org/10.3390/antiox9040269
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author Ramiro-Cortijo, David
de la Calle, María
Rodríguez-Rodríguez, Pilar
López de Pablo, Ángel L.
López-Giménez, María R.
Aguilera, Yolanda
Martín-Cabrejas, María A.
González, María del Carmen
Arribas, Silvia M.
author_facet Ramiro-Cortijo, David
de la Calle, María
Rodríguez-Rodríguez, Pilar
López de Pablo, Ángel L.
López-Giménez, María R.
Aguilera, Yolanda
Martín-Cabrejas, María A.
González, María del Carmen
Arribas, Silvia M.
author_sort Ramiro-Cortijo, David
collection PubMed
description Twin pregnancies are increasing due to the rise in mothers’ childbearing age and have a higher risk of fetal growth restriction (FGR) and prematurity. Therefore, early prediction of these events is important. Our aim was to analyze in the first trimester of pregnancy a possible association between antioxidants, including melatonin, in maternal plasma and the development of fetal complications in twin pregnancies. A single-center, prospective, and observational study was performed in 104 twin-pregnant women. A blood sample was extracted between the 9th and the 11th week of gestation, and plasma was obtained. Antioxidants (thiols, reduced glutathione, phenolic compounds, catalase, superoxide dismutase) and oxidative damage biomarkers (carbonyl groups and malondialdehyde) were assessed by spectrophotometry, and global scores were calculated from these parameters (Antiox-S, Prooxy-S). Melatonin and cortisol were evaluated by a competitive immunoassay. In the first trimester of pregnancy, Antiox-S was significantly lower in women who developed FGR compared to those with normal fetal growth; plasma melatonin was significantly lower in women with preterm compared to those with full-term births and exhibited a positive correlation with birth weight. Maternal cortisol showed a negative correlation with birth weight. We conclude that, for twin gestations, maternal plasma antioxidant status and melatonin could be potential biomarkers to be included in algorithms to predict FGR and preterm labor.
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spelling pubmed-72221782020-05-28 Maternal Antioxidant Status in Early Pregnancy and Development of Fetal Complications in Twin Pregnancies: A Pilot Study Ramiro-Cortijo, David de la Calle, María Rodríguez-Rodríguez, Pilar López de Pablo, Ángel L. López-Giménez, María R. Aguilera, Yolanda Martín-Cabrejas, María A. González, María del Carmen Arribas, Silvia M. Antioxidants (Basel) Article Twin pregnancies are increasing due to the rise in mothers’ childbearing age and have a higher risk of fetal growth restriction (FGR) and prematurity. Therefore, early prediction of these events is important. Our aim was to analyze in the first trimester of pregnancy a possible association between antioxidants, including melatonin, in maternal plasma and the development of fetal complications in twin pregnancies. A single-center, prospective, and observational study was performed in 104 twin-pregnant women. A blood sample was extracted between the 9th and the 11th week of gestation, and plasma was obtained. Antioxidants (thiols, reduced glutathione, phenolic compounds, catalase, superoxide dismutase) and oxidative damage biomarkers (carbonyl groups and malondialdehyde) were assessed by spectrophotometry, and global scores were calculated from these parameters (Antiox-S, Prooxy-S). Melatonin and cortisol were evaluated by a competitive immunoassay. In the first trimester of pregnancy, Antiox-S was significantly lower in women who developed FGR compared to those with normal fetal growth; plasma melatonin was significantly lower in women with preterm compared to those with full-term births and exhibited a positive correlation with birth weight. Maternal cortisol showed a negative correlation with birth weight. We conclude that, for twin gestations, maternal plasma antioxidant status and melatonin could be potential biomarkers to be included in algorithms to predict FGR and preterm labor. MDPI 2020-03-25 /pmc/articles/PMC7222178/ /pubmed/32218124 http://dx.doi.org/10.3390/antiox9040269 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ramiro-Cortijo, David
de la Calle, María
Rodríguez-Rodríguez, Pilar
López de Pablo, Ángel L.
López-Giménez, María R.
Aguilera, Yolanda
Martín-Cabrejas, María A.
González, María del Carmen
Arribas, Silvia M.
Maternal Antioxidant Status in Early Pregnancy and Development of Fetal Complications in Twin Pregnancies: A Pilot Study
title Maternal Antioxidant Status in Early Pregnancy and Development of Fetal Complications in Twin Pregnancies: A Pilot Study
title_full Maternal Antioxidant Status in Early Pregnancy and Development of Fetal Complications in Twin Pregnancies: A Pilot Study
title_fullStr Maternal Antioxidant Status in Early Pregnancy and Development of Fetal Complications in Twin Pregnancies: A Pilot Study
title_full_unstemmed Maternal Antioxidant Status in Early Pregnancy and Development of Fetal Complications in Twin Pregnancies: A Pilot Study
title_short Maternal Antioxidant Status in Early Pregnancy and Development of Fetal Complications in Twin Pregnancies: A Pilot Study
title_sort maternal antioxidant status in early pregnancy and development of fetal complications in twin pregnancies: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222178/
https://www.ncbi.nlm.nih.gov/pubmed/32218124
http://dx.doi.org/10.3390/antiox9040269
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