Cargando…

N(6)-methyladenosine demethylases Alkbh5/Fto regulate cerebral ischemia-reperfusion injury

BACKGROUND: Although N(6)-methyladenosine (m(6)A) plays a very important role in different biological processes, its function in the brain has not been fully explored. Thus, we investigated the roles of the RNA demethylases Alkbh5/Fto in cerebral ischemia-reperfusion injury. METHODS: We used a rat m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Kaiwei, Mo, Yunchang, Li, Dan, Yu, Qimin, Wang, Lu, Lin, Feihong, Kong, Chang, Balelang, Meita Felicia, Zhang, Anqi, Chen, Sijia, Dai, Qinxue, Wang, Junlu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222229/ https://www.ncbi.nlm.nih.gov/pubmed/32426101 http://dx.doi.org/10.1177/2040622320916024

Ejemplares similares

Electroacupuncture pre-conditioning protects from lung injury induced by limb ischemia/reperfusion through TLR4 and NF-κB in rats
por: Lou, Yingying, et al.
Publicado: (2020)

Electroacupuncture Pretreatment Alleviates Cerebral Ischemia-Reperfusion Injury by Increasing GSK-3β Phosphorylation Level via Adenosine A1 Receptor
por: Geng, Wujun, et al.
Publicado: (2020)

N(6)-Methyladenosine: a conformational marker that regulates the substrate specificity of human demethylases FTO and ALKBH5
por: Zou, Shui, et al.
Publicado: (2016)

Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer
por: Li, Yue, et al.
Publicado: (2019)

N6-methyladenosine demethylase FTO impairs hepatic ischemia–reperfusion injury via inhibiting Drp1-mediated mitochondrial fragmentation
por: Du, Ying Dong, et al.
Publicado: (2021)

DCA Protects against Oxidation Injury Attributed to Cerebral Ischemia-Reperfusion by Regulating Glycolysis through PDK2-PDH-Nrf2 Axis
por: Zhao, Xiaoyong, et al.
Publicado: (2021)

The N6-methyladenosine demethylase ALKBH5 regulates the hypoxic HBV transcriptome.
por: Tsukuda, Senko, et al.
Publicado: (2023)

Promoting axon regeneration by inhibiting RNA N6-methyladenosine demethylase ALKBH5
por: Wang, Dong, et al.
Publicado: (2023)

Electroacupuncture Pretreatment Prevents Cognitive Impairment Induced by Cerebral Ischemia–Reperfusion via Adenosine A1 Receptors in Rats
por: Shi, Yiyi, et al.
Publicado: (2021)

Roles of N6‐Methyladenosine Demethylase FTO in Malignant Tumors Progression
por: Zheng, Qing-Kang, et al.
Publicado: (2021)

Glycogen synthase kinase-3β mediates toll-like receptors 4/nuclear factor kappa-B-activated cerebral ischemia-reperfusion injury through regulation of fat mass and obesity-associated protein
por: Xu, Kaiwei, et al.
Publicado: (2023)

Impact of m6A demethylase (ALKBH5, FTO) genetic polymorphism and expression levels on the development of pulmonary tuberculosis
por: Zhang, Tian-Ping, et al.
Publicado: (2022)

N (6) -methyladenosine demethylase ALKBH5: a novel regulator of proliferation and differentiation of chicken preadipocytes : ALKBH5 regulated preadipocyte proliferation and differentiation
por: Zhang, Qi, et al.
Publicado: (2021)

The Effect of Transcutaneous Electrical Acupoint Stimulation on Inflammatory Response in Patients Undergoing Limb Ischemia-Reperfusion
por: Mo, Yunchang, et al.
Publicado: (2017)

25-Hydroxycholesterol protecting from cerebral ischemia-reperfusion injury through the inhibition of STING activity
por: Lin, Feihong, et al.
Publicado: (2021)

Nitric oxide inhibits FTO demethylase activity to regulate N(6)-methyladenosine mRNA methylation
por: Kuschman, Hannah Petraitis, et al.
Publicado: (2023)

The N(6)-methyladenosine demethylase ALKBH5 negatively regulates the osteogenic differentiation of mesenchymal stem cells through PRMT6
por: Li, Zhaofeng, et al.
Publicado: (2021)

N(6)-methyladenosine binding induces a metal-centered rearrangement that activates the human RNA demethylase Alkbh5
por: Purslow, Jeffrey A., et al.
Publicado: (2021)

N6‐methyladenosine demethylase ALKBH5 suppresses colorectal cancer progression potentially by decreasing PHF20 mRNA methylation
por: Zhang, Zhen, et al.
Publicado: (2022)

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
por: Niu, Yi, et al.
Publicado: (2019)

m(6)A demethylase FTO regulates the apoptosis and inflammation of cardiomyocytes via YAP1 in ischemia-reperfusion injury
por: Ke, Wei-Liang, et al.
Publicado: (2022)

Identification of epistatic interactions between the human RNA demethylases FTO and ALKBH5 with gene set enrichment analysis informed by differential methylation
por: Piette, Elizabeth R., et al.
Publicado: (2018)

Deregulation of N6-Methyladenosine RNA Modification and Its Erasers FTO/ALKBH5 among the Main Renal Cell Tumor Subtypes
por: Guimarães-Teixeira, Catarina, et al.
Publicado: (2021)

N(6)‐Methyladenosine Demethylase FTO Contributes to Neuropathic Pain by Stabilizing G9a Expression in Primary Sensory Neurons
por: Li, Yize, et al.
Publicado: (2020)

N6‐methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO‐PGC‐1α signalling axis
por: Zhuang, Changshui, et al.
Publicado: (2019)

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing
por: Bartosovic, Marek, et al.
Publicado: (2017)

A fluorescent methylation-switchable probe for highly sensitive analysis of FTO N(6)-methyladenosine demethylase activity in cells
por: Cheong, Adeline, et al.
Publicado: (2018)

N6-methyladenosine demethylase FTO suppressed prostate cancer progression by maintaining CLIC4 mRNA stability
por: Zou, Libin, et al.
Publicado: (2022)

A novel inhibitor of N(6)-methyladenosine demethylase FTO induces mRNA methylation and shows anti-cancer activities
por: Xie, Guoyou, et al.
Publicado: (2022)

ICA69 aggravates ferroptosis causing septic cardiac dysfunction via STING trafficking
por: Kong, Chang, et al.
Publicado: (2022)

The RNA N6-Methyladenosine Demethylase FTO Promotes Head and Neck Squamous Cell Carcinoma Proliferation and Migration by Increasing CTNNB1
por: Zhang, Yu, et al.
Publicado: (2021)

The Potential Role of N6-Methyladenosine (m6A) Demethylase Fat Mass and Obesity-Associated Gene (FTO) in Human Cancers
por: Wang, Jin-yan, et al.
Publicado: (2020)

RNA N6-methyladenosine demethylase FTO promotes osteoporosis through demethylating Runx2 mRNA and inhibiting osteogenic differentiation
por: Wang, Jing, et al.
Publicado: (2021)

N(6) ‐methyladenosine RNA demethylase FTO regulates extracellular matrix‐related genes and promotes pancreatic cancer cell migration and invasion
por: Wang, Wei, et al.
Publicado: (2022)

Electroacupuncture Attenuates CFA-Induced Inflammatory Pain by Regulating CaMKII
por: Gu, Yixiao, et al.
Publicado: (2020)

N(6)-Methyladenosine RNA Demethylase FTO Promotes Gastric Cancer Metastasis by Down-Regulating the m6A Methylation of ITGB1
por: Wang, Duo, et al.
Publicado: (2021)

Targeting the RNA demethylase FTO for cancer therapy
por: Zhou, Lin-Lin, et al.
Publicado: (2021)

RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential
por: Qu, Jianwei, et al.
Publicado: (2022)

A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N (6)-methyladenosine demethylase FTO
por: Toh, Joel D. W., et al.
Publicado: (2015)

Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase
por: Marcinkowski, Michał, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_e0lkbiogqplns0uq867n6b43d3