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Polymer nanoparticle-assisted chemotherapy of pancreatic cancer

Pancreatic cancer is a lethal disease characterized by highly dense stroma fibrosis. Only 15–20% of patients with pancreatic cancer have resectable tumors, and only around 20% of them survive to 5 years. Traditional cancer treatments have little effect on their prognosis, and successful surgical res...

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Detalles Bibliográficos
Autores principales: Su, Tianqi, Yang, Bo, Gao, Tianren, Liu, Tongjun, Li, Jiannan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222269/
https://www.ncbi.nlm.nih.gov/pubmed/32426046
http://dx.doi.org/10.1177/1758835920915978
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author Su, Tianqi
Yang, Bo
Gao, Tianren
Liu, Tongjun
Li, Jiannan
author_facet Su, Tianqi
Yang, Bo
Gao, Tianren
Liu, Tongjun
Li, Jiannan
author_sort Su, Tianqi
collection PubMed
description Pancreatic cancer is a lethal disease characterized by highly dense stroma fibrosis. Only 15–20% of patients with pancreatic cancer have resectable tumors, and only around 20% of them survive to 5 years. Traditional cancer treatments have little effect on their prognosis, and successful surgical resection combined with effective perioperative therapy is the main method for maximizing long-term survival. For this reason, chemotherapy is an adjunct treatment for resectable cancer and is the main therapy for incurable pancreatic cancer, including metastatic pancreatic adenocarcinoma. However, there are various side effects of chemotherapeutic medicine and low drug penetration because the complex tumor microenvironment limits the application of chemotherapy. As a novel strategy, polymer nanoparticles make it possible to target the tumor microenvironment, release cytotoxic agents through various responsive reactions, and thus overcome the treatment barrier. As drug carriers, polymer nanoparticles show marked advantages, such as increased drug delivery and efficiency, controlled drug release, decreased side effects, prolonged half-life, and evasion of immunogenic blockade. In this review, we discuss the factors that cause chemotherapy obstacles in pancreatic cancer, and introduce the application of polymer nanoparticles to treat pancreatic cancer.
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spelling pubmed-72222692020-05-18 Polymer nanoparticle-assisted chemotherapy of pancreatic cancer Su, Tianqi Yang, Bo Gao, Tianren Liu, Tongjun Li, Jiannan Ther Adv Med Oncol Review Pancreatic cancer is a lethal disease characterized by highly dense stroma fibrosis. Only 15–20% of patients with pancreatic cancer have resectable tumors, and only around 20% of them survive to 5 years. Traditional cancer treatments have little effect on their prognosis, and successful surgical resection combined with effective perioperative therapy is the main method for maximizing long-term survival. For this reason, chemotherapy is an adjunct treatment for resectable cancer and is the main therapy for incurable pancreatic cancer, including metastatic pancreatic adenocarcinoma. However, there are various side effects of chemotherapeutic medicine and low drug penetration because the complex tumor microenvironment limits the application of chemotherapy. As a novel strategy, polymer nanoparticles make it possible to target the tumor microenvironment, release cytotoxic agents through various responsive reactions, and thus overcome the treatment barrier. As drug carriers, polymer nanoparticles show marked advantages, such as increased drug delivery and efficiency, controlled drug release, decreased side effects, prolonged half-life, and evasion of immunogenic blockade. In this review, we discuss the factors that cause chemotherapy obstacles in pancreatic cancer, and introduce the application of polymer nanoparticles to treat pancreatic cancer. SAGE Publications 2020-05-08 /pmc/articles/PMC7222269/ /pubmed/32426046 http://dx.doi.org/10.1177/1758835920915978 Text en © The Author(s), 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Su, Tianqi
Yang, Bo
Gao, Tianren
Liu, Tongjun
Li, Jiannan
Polymer nanoparticle-assisted chemotherapy of pancreatic cancer
title Polymer nanoparticle-assisted chemotherapy of pancreatic cancer
title_full Polymer nanoparticle-assisted chemotherapy of pancreatic cancer
title_fullStr Polymer nanoparticle-assisted chemotherapy of pancreatic cancer
title_full_unstemmed Polymer nanoparticle-assisted chemotherapy of pancreatic cancer
title_short Polymer nanoparticle-assisted chemotherapy of pancreatic cancer
title_sort polymer nanoparticle-assisted chemotherapy of pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222269/
https://www.ncbi.nlm.nih.gov/pubmed/32426046
http://dx.doi.org/10.1177/1758835920915978
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