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Proteoglycan-4 regulates fibroblast to myofibroblast transition and expression of fibrotic genes in the synovium

BACKGROUND: Synovial tissue fibrosis is common in advanced OA with features including the presence of stress fiber-positive myofibroblasts and deposition of cross-linked collagen type-I. Proteoglycan-4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and is a major component of syn...

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Detalles Bibliográficos
Autores principales:	Qadri, Marwa, Jay, Gregory D., Zhang, Ling X., Richendrfer, Holly, Schmidt, Tannin A., Elsaid, Khaled A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222325/ https://www.ncbi.nlm.nih.gov/pubmed/32404156 http://dx.doi.org/10.1186/s13075-020-02207-x

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