ERα-related chromothripsis enhances concordant gene transcription on chromosome 17q11.1-q24.1 in luminal breast cancer

BACKGROUND: Chromothripsis is an event of genomic instability leading to complex chromosomal alterations in cancer. Frequent long-range chromatin interactions between transcription factors (TFs) and targets may promote extensive translocations and copy-number alterations in proximal contact regions...

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Detalles Bibliográficos
Autores principales: Lin, Chun-Lin, Tan, Xi, Chen, Meizhen, Kusi, Meena, Hung, Chia-Nung, Chou, Chih-Wei, Hsu, Ya-Ting, Wang, Chiou-Miin, Kirma, Nameer, Chen, Chun-Liang, Lin, Ching-Hung, Lathrop, Kate I., Elledge, Richard, Kaklamani, Virginia G., Mitsuya, Kohzoh, Huang, Tim H.-M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222439/
https://www.ncbi.nlm.nih.gov/pubmed/32408897
http://dx.doi.org/10.1186/s12920-020-0729-7

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