Cargando…

Mouse Umbilical Cord Mesenchymal Stem Cell Paracrine Alleviates Renal Fibrosis in Diabetic Nephropathy by Reducing Myofibroblast Transdifferentiation and Cell Proliferation and Upregulating MMPs in Mesangial Cells

Transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) is currently considered a novel therapeutic strategy for diabetic nephropathy (DN). However, the mechanisms by which UC-MSCs ameliorate renal fibrosis in DN are not well understood. Herein, we firstly investigated the therapeutic eff...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Hongde, Rong, Pengfei, Ma, Xiaoqian, Nie, Wei, Chen, Yan, Zhang, Juan, Dong, Qiong, Yang, Min, Wang, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222483/ https://www.ncbi.nlm.nih.gov/pubmed/32455132 http://dx.doi.org/10.1155/2020/3847171

Ejemplares similares

The signal pathway for the repressive effect of dipyridamole on myofibroblast transdifferentiation
por: Yan, Qiong, et al.
Publicado: (2018)

Lefty-1 alleviates TGF-β1-induced fibroblast–myofibroblast transdifferentiation in NRK-49F cells
por: Zhang, Lijun, et al.
Publicado: (2015)

Telomere dysfunction promotes transdifferentiation of human fibroblasts into myofibroblasts
por: Razdan, Neetu, et al.
Publicado: (2018)

Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models
por: Yao, Qin, et al.
Publicado: (2009)

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis
por: Meng, Xiao-Ming, et al.
Publicado: (2016)

Effects of cyclosporin, nifedipine and phenytoin on gingival myofibroblast transdifferentiation in monkeys
por: Kanno, Claudia Misue, et al.
Publicado: (2018)

Retraction: Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models
por: Yao, Qin, et al.
Publicado: (2009)

Role of Mononuclear Cells of IgA Nephropathy on ICAM-1 Expression in Mesangial Cells
por: Lee, Tae-Won, et al.
Publicado: (1998)

YAP activation promotes the transdifferentiation of cardiac fibroblasts to myofibroblasts in matrix remodeling of dilated cardiomyopathy
por: Jin, Bo, et al.
Publicado: (2018)

Changes in the gene expression programs of renal mesangial cells during diabetic nephropathy
por: Brunskill, Eric W, et al.
Publicado: (2012)

NAD(+) Anabolism Disturbance Causes Glomerular Mesangial Cell Injury in Diabetic Nephropathy
por: Li, Xue, et al.
Publicado: (2022)

Zebularine suppresses TGF-beta-induced lens epithelial cell–myofibroblast transdifferentiation by inhibiting MeCP2
por: Zhou, Peng, et al.
Publicado: (2011)

Epidermal Paracrine Signals May Regulate Dupuytren Contracture Myofibroblasts
por: Drinane, James, et al.
Publicado: (2021)

The Combination of Electroacupuncture and Massage Therapy Alleviates Myofibroblast Transdifferentiation and Extracellular Matrix Production in Blunt Trauma-Induced Skeletal Muscle Fibrosis
por: Zhao, Na, et al.
Publicado: (2021)

Pathophysiology of mesangial expansion in diabetic nephropathy: mesangial structure, glomerular biomechanics, and biochemical signaling and regulation
por: Thomas, Haryana Y., et al.
Publicado: (2022)

AR12286 Alleviates TGF-β-Related Myofibroblast Transdifferentiation and Reduces Fibrosis after Glaucoma Filtration Surgery
por: Cheng, Wen-Sheng, et al.
Publicado: (2020)

Swimming Exercise Prevents Fibrogenesis in Chronic Kidney Disease by Inhibiting the Myofibroblast Transdifferentiation
por: Peng, Chiung-Chi, et al.
Publicado: (2012)

Role of Heat Shock Protein 47 in Transdifferentiation of Human Tenon's Fibroblasts to Myofibroblasts
por: Hong, Samin, et al.
Publicado: (2012)

Nintedanib inhibits TGF-β-induced myofibroblast transdifferentiation in human Tenon’s fibroblasts
por: Lin, Xianchai, et al.
Publicado: (2018)

GED-0507 attenuates lung fibrosis by counteracting myofibroblast transdifferentiation in vivo and in vitro
por: Speca, Silvia, et al.
Publicado: (2021)

Myofibroblast transdifferentiation is associated with changes in cellular and extracellular vesicle miRNA abundance
por: Zainal Abidin, Siti Amalina Inche, et al.
Publicado: (2021)

Myofibroblast transdifferentiation of keratocytes results in slower migration and lower sensitivity to mesoscale curvatures
por: van der Putten, Cas, et al.
Publicado: (2022)

SARA suppresses myofibroblast precursor transdifferentiation in fibrogenesis in a mouse model of scleroderma
por: Corano Scheri, Katia, et al.
Publicado: (2022)

Curcumin alleviates diabetic nephropathy via inhibiting podocyte mesenchymal transdifferentiation and inducing autophagy in rats and MPC5 cells
por: Tu, Qiudi, et al.
Publicado: (2019)

Arecoline-induced myofibroblast transdifferentiation from human buccal mucosal fibroblasts is mediated by ZEB1
por: Chang, Yu-Chao, et al.
Publicado: (2014)

Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes
por: Manda, Gina, et al.
Publicado: (2015)

Gut-kidney axis in IgA nephropathy: Role on mesangial cell metabolism and inflammation
por: Luvizotto, Mateus Justi, et al.
Publicado: (2022)

P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor β1 expression
por: Li, Haisheng, et al.
Publicado: (2016)

Benzalkonium chloride-induced myofibroblastic transdifferentiation of Tenon’s capsule fibroblasts is inhibited by coculture with corneal epithelial cells or by interleukin-10
por: Yamashiro, Chiemi, et al.
Publicado: (2021)

Hepatic SATB1 induces paracrine activation of hepatic stellate cells and is upregulated by HBx
por: Gong, Jin, et al.
Publicado: (2016)

TGF-β-induced interleukin-6 participates in transdifferentiation of human Tenon’s fibroblasts to myofibroblasts
por: Seong, Gong Je, et al.
Publicado: (2009)

Histone Methyltransferase ASH1 Orchestrates Fibrogenic Gene Transcription During Myofibroblast Transdifferentiation
por: Perugorria, Maria Jesus, et al.
Publicado: (2012)

Vincristine Promotes Transdifferentiation of Fibroblasts Into Myofibroblasts via P38 and ERK Signal Pathways
por: Xu, Hui, et al.
Publicado: (2022)

Selective Inhibition of Bromodomain-Containing Protein 4 Reduces Myofibroblast Transdifferentiation and Pulmonary Fibrosis
por: Bernau, Ksenija, et al.
Publicado: (2022)

AS101 Prevents Diabetic Nephropathy Progression and Mesangial Cell Dysfunction: Regulation of the AKT Downstream Pathway
por: Shemesh, Itay Israel, et al.
Publicado: (2014)

Hyperglycemia induced damage to mitochondrial respiration in renal mesangial and tubular cells: Implications for diabetic nephropathy
por: Czajka, Anna, et al.
Publicado: (2016)

Corrigendum to “Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes”
por: Manda, Gina, et al.
Publicado: (2018)

Identification of IgA autoantibodies targeting mesangial cells redefines the pathogenesis of IgA nephropathy
por: Nihei, Yoshihito, et al.
Publicado: (2023)

Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy
por: Gan, Lu, et al.
Publicado: (2018)

Aberrant Hedgehog Ligands Induce Progressive Pancreatic Fibrosis by Paracrine Activation of Myofibroblasts and Ductular Cells in Transgenic Zebrafish
por: Jung, In Hye, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_vb2h91bs5ds9v839cek0s8b745