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Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis
Inflammatory diseases are a real public health problem worldwide. Many synthetic drugs used in the treatment of inflammatory diseases such as steroidal anti-inflammatory drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) and immunosuppressive drugs have harmful side effects. However, there are nat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222486/ https://www.ncbi.nlm.nih.gov/pubmed/32462026 http://dx.doi.org/10.1155/2020/8797284 |
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author | Sokeng, Sélestin Dongmo Talla, Emmanuel Sakava, Paul Fokam Tagne, Michel Archange Henoumont, Celine Sophie, Laurent Mbafor, Joseph Tanyi Tchuenguem Fohouo, Fernand-Nestor |
author_facet | Sokeng, Sélestin Dongmo Talla, Emmanuel Sakava, Paul Fokam Tagne, Michel Archange Henoumont, Celine Sophie, Laurent Mbafor, Joseph Tanyi Tchuenguem Fohouo, Fernand-Nestor |
author_sort | Sokeng, Sélestin Dongmo |
collection | PubMed |
description | Inflammatory diseases are a real public health problem worldwide. Many synthetic drugs used in the treatment of inflammatory diseases such as steroidal anti-inflammatory drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) and immunosuppressive drugs have harmful side effects. However, there are natural products like propolis, which is traditionally used in the treatment of pain. The objective of this work was to evaluate the anti-inflammatory and analgesic activities of the ethyl ester of arachic acid, a compound isolated from Cameroonian propolis. The ethyl ester of arachic acid was isolated by chromatography of the ethanolic extract of propolis harvested at Tala-Mokolo (Far North Region of Cameroon) and identified by nuclear magnetic resonance (NMR) spectra and the (1)H-(1)H correlated spectroscopy. The anti-inflammatory and analgesic properties of oral administration of arachic acid ethyl ester (12.5, 25.0, and 50.0 mg/kg bw) were evaluated using carrageenan-induced paw edema, xylene-induced ear edema, cotton pellets-induced granuloma formation, and hot plate test in rat. Arachic acid ethyl ester produced maximum inhibition at 50.0 mg/kg for carrageenan-induced paw edema (62.5%), xylene-induced ear edema (54.5%), cotton pellet-induced granuloma (47.4%), and increased mean latency for hot plate test in rats. These results show clearly that the arachic acid ethyl ester has acute and chronic anti-inflammatory properties as well as central analgesic properties. This justifies the use of propolis in the treatment of pain in traditional medicine. |
format | Online Article Text |
id | pubmed-7222486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-72224862020-05-26 Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis Sokeng, Sélestin Dongmo Talla, Emmanuel Sakava, Paul Fokam Tagne, Michel Archange Henoumont, Celine Sophie, Laurent Mbafor, Joseph Tanyi Tchuenguem Fohouo, Fernand-Nestor Biomed Res Int Research Article Inflammatory diseases are a real public health problem worldwide. Many synthetic drugs used in the treatment of inflammatory diseases such as steroidal anti-inflammatory drugs, nonsteroidal anti-inflammatory drugs (NSAIDs) and immunosuppressive drugs have harmful side effects. However, there are natural products like propolis, which is traditionally used in the treatment of pain. The objective of this work was to evaluate the anti-inflammatory and analgesic activities of the ethyl ester of arachic acid, a compound isolated from Cameroonian propolis. The ethyl ester of arachic acid was isolated by chromatography of the ethanolic extract of propolis harvested at Tala-Mokolo (Far North Region of Cameroon) and identified by nuclear magnetic resonance (NMR) spectra and the (1)H-(1)H correlated spectroscopy. The anti-inflammatory and analgesic properties of oral administration of arachic acid ethyl ester (12.5, 25.0, and 50.0 mg/kg bw) were evaluated using carrageenan-induced paw edema, xylene-induced ear edema, cotton pellets-induced granuloma formation, and hot plate test in rat. Arachic acid ethyl ester produced maximum inhibition at 50.0 mg/kg for carrageenan-induced paw edema (62.5%), xylene-induced ear edema (54.5%), cotton pellet-induced granuloma (47.4%), and increased mean latency for hot plate test in rats. These results show clearly that the arachic acid ethyl ester has acute and chronic anti-inflammatory properties as well as central analgesic properties. This justifies the use of propolis in the treatment of pain in traditional medicine. Hindawi 2020-05-03 /pmc/articles/PMC7222486/ /pubmed/32462026 http://dx.doi.org/10.1155/2020/8797284 Text en Copyright © 2020 Sélestin Dongmo Sokeng et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sokeng, Sélestin Dongmo Talla, Emmanuel Sakava, Paul Fokam Tagne, Michel Archange Henoumont, Celine Sophie, Laurent Mbafor, Joseph Tanyi Tchuenguem Fohouo, Fernand-Nestor Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis |
title | Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis |
title_full | Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis |
title_fullStr | Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis |
title_full_unstemmed | Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis |
title_short | Anti-Inflammatory and Analgesic Effect of Arachic Acid Ethyl Ester Isolated from Propolis |
title_sort | anti-inflammatory and analgesic effect of arachic acid ethyl ester isolated from propolis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222486/ https://www.ncbi.nlm.nih.gov/pubmed/32462026 http://dx.doi.org/10.1155/2020/8797284 |
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