Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock

BACKGROUND: Polynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound carbon monoxide prevents methemoglobin formation during storage and permits it...

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Detalles Bibliográficos
Autores principales: Seno, Soichiro, Wang, Jun, Cao, Suyi, Saraswati, Manda, Park, Sharon, Simoni, Jan, Ma, Li, Soltys, Bohdan, Hsia, Carleton J. C., Koehler, Raymond C., Robertson, Courtney L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222507/
https://www.ncbi.nlm.nih.gov/pubmed/32404052
http://dx.doi.org/10.1186/s12868-020-00571-7

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