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Quantitative prediction of selectivity between the A(1) and A(2A) adenosine receptors
The development of drugs is often hampered due to off-target interactions leading to adverse effects. Therefore, computational methods to assess the selectivity of ligands are of high interest. Currently, selectivity is often deduced from bioactivity predictions of a ligand for multiple targets (ind...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222572/ https://www.ncbi.nlm.nih.gov/pubmed/33431012 http://dx.doi.org/10.1186/s13321-020-00438-3 |