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An Analysis of the Anti-Neuropathic Effects of Qi She Pill Based on Network Pharmacology
BACKGROUND: Qi She Pill (QSP) is a traditional prescription for the treatment of neuropathic pain (NP) that is widely used in China. However, no network pharmacology studies of QSP in the treatment of NP have been conducted to date. OBJECTIVE: To verify the potential pharmacological effects of QSP o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222608/ https://www.ncbi.nlm.nih.gov/pubmed/32454869 http://dx.doi.org/10.1155/2020/7193832 |
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author | Song, Yong-jia Bao, Jia-min Zhou, Long-yun Li, Gan Sng, Kim Sia Wang, Yong-jun Shi, Qi Cui, Xue-jun |
author_facet | Song, Yong-jia Bao, Jia-min Zhou, Long-yun Li, Gan Sng, Kim Sia Wang, Yong-jun Shi, Qi Cui, Xue-jun |
author_sort | Song, Yong-jia |
collection | PubMed |
description | BACKGROUND: Qi She Pill (QSP) is a traditional prescription for the treatment of neuropathic pain (NP) that is widely used in China. However, no network pharmacology studies of QSP in the treatment of NP have been conducted to date. OBJECTIVE: To verify the potential pharmacological effects of QSP on NP, its components were analyzed via target docking and network analysis, and network pharmacology methods were used to study the interactions of its components. MATERIALS AND METHODS: Information on pharmaceutically active compounds in QSP and gene information related to NP were obtained from public databases, and a compound-target network and protein-protein interaction network were constructed to study the mechanism of action of QSP in the treatment of NP. The mechanism of action of QSP in the treatment of NP was analyzed via Gene Ontology (GO) biological process annotation and Kyoto Gene and Genomics Encyclopedia (KEGG) pathway enrichment, and the drug-like component-target-pathway network was constructed. RESULTS: The compound-target network contained 60 compounds and 444 corresponding targets. The key active compounds included quercetin and beta-sitosterol. Key targets included PTGS2 and PTGS1. The protein-protein interaction network of the active ingredients of QSP in the treatment of NP featured 48 proteins, including DRD2, CHRM, β2-adrenergic receptor, HTR2A, and calcitonin gene-related peptide. In total, 53 GO entries, including 35 biological process items, 7 molecular function items, and 11 cell related items, were identified. In addition, eight relevant (KEGG) pathways were identified, including calcium, neuroactive ligand-receptor interaction, and cAMP signaling pathways. CONCLUSION: Network pharmacology can help clarify the role and mechanism of QSP in the treatment of NP and provide a foundation for further research. |
format | Online Article Text |
id | pubmed-7222608 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-72226082020-05-23 An Analysis of the Anti-Neuropathic Effects of Qi She Pill Based on Network Pharmacology Song, Yong-jia Bao, Jia-min Zhou, Long-yun Li, Gan Sng, Kim Sia Wang, Yong-jun Shi, Qi Cui, Xue-jun Evid Based Complement Alternat Med Research Article BACKGROUND: Qi She Pill (QSP) is a traditional prescription for the treatment of neuropathic pain (NP) that is widely used in China. However, no network pharmacology studies of QSP in the treatment of NP have been conducted to date. OBJECTIVE: To verify the potential pharmacological effects of QSP on NP, its components were analyzed via target docking and network analysis, and network pharmacology methods were used to study the interactions of its components. MATERIALS AND METHODS: Information on pharmaceutically active compounds in QSP and gene information related to NP were obtained from public databases, and a compound-target network and protein-protein interaction network were constructed to study the mechanism of action of QSP in the treatment of NP. The mechanism of action of QSP in the treatment of NP was analyzed via Gene Ontology (GO) biological process annotation and Kyoto Gene and Genomics Encyclopedia (KEGG) pathway enrichment, and the drug-like component-target-pathway network was constructed. RESULTS: The compound-target network contained 60 compounds and 444 corresponding targets. The key active compounds included quercetin and beta-sitosterol. Key targets included PTGS2 and PTGS1. The protein-protein interaction network of the active ingredients of QSP in the treatment of NP featured 48 proteins, including DRD2, CHRM, β2-adrenergic receptor, HTR2A, and calcitonin gene-related peptide. In total, 53 GO entries, including 35 biological process items, 7 molecular function items, and 11 cell related items, were identified. In addition, eight relevant (KEGG) pathways were identified, including calcium, neuroactive ligand-receptor interaction, and cAMP signaling pathways. CONCLUSION: Network pharmacology can help clarify the role and mechanism of QSP in the treatment of NP and provide a foundation for further research. Hindawi 2020-05-04 /pmc/articles/PMC7222608/ /pubmed/32454869 http://dx.doi.org/10.1155/2020/7193832 Text en Copyright © 2020 Yong-jia Song et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Song, Yong-jia Bao, Jia-min Zhou, Long-yun Li, Gan Sng, Kim Sia Wang, Yong-jun Shi, Qi Cui, Xue-jun An Analysis of the Anti-Neuropathic Effects of Qi She Pill Based on Network Pharmacology |
title | An Analysis of the Anti-Neuropathic Effects of Qi She Pill Based on Network Pharmacology |
title_full | An Analysis of the Anti-Neuropathic Effects of Qi She Pill Based on Network Pharmacology |
title_fullStr | An Analysis of the Anti-Neuropathic Effects of Qi She Pill Based on Network Pharmacology |
title_full_unstemmed | An Analysis of the Anti-Neuropathic Effects of Qi She Pill Based on Network Pharmacology |
title_short | An Analysis of the Anti-Neuropathic Effects of Qi She Pill Based on Network Pharmacology |
title_sort | analysis of the anti-neuropathic effects of qi she pill based on network pharmacology |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7222608/ https://www.ncbi.nlm.nih.gov/pubmed/32454869 http://dx.doi.org/10.1155/2020/7193832 |
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