Streptovertimycins A–H, new fasamycin-type antibiotics produced by a soil-derived Streptomyces morookaense strain

Eight new fasamycin-type polyketides, streptovertimycins A–H (1−8), were isolated from soil-derived Streptomyces morookaense SC1169 cultivated on wheat grains. Their structures were established by extensive spectroscopic analysis and theoretical computations of ECD spectra. Compounds 1−8 have a fasa...

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Detalles Bibliográficos
Autores principales: Yang, Li, Li, Xiaoxia, Wu, Ping, Xue, Jinghua, Xu, Liangxiong, Li, Hanxiang, Wei, Xiaoyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223045/
https://www.ncbi.nlm.nih.gov/pubmed/31949315
http://dx.doi.org/10.1038/s41429-020-0277-6
Descripción
Sumario:Eight new fasamycin-type polyketides, streptovertimycins A–H (1−8), were isolated from soil-derived Streptomyces morookaense SC1169 cultivated on wheat grains. Their structures were established by extensive spectroscopic analysis and theoretical computations of ECD spectra. Compounds 1−8 have a fasamycin-type pentacyclic structure featuring a 15-O-methyl group. They exhibited potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) with MIC values in the range of 0.63–5.0 μg/ml. The activity profile provided new insights into the structure–activity relationships of fasamycin-type antibiotics.

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