Streptovertimycins A–H, new fasamycin-type antibiotics produced by a soil-derived Streptomyces morookaense strain

Eight new fasamycin-type polyketides, streptovertimycins A–H (1−8), were isolated from soil-derived Streptomyces morookaense SC1169 cultivated on wheat grains. Their structures were established by extensive spectroscopic analysis and theoretical computations of ECD spectra. Compounds 1−8 have a fasa...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Li, Li, Xiaoxia, Wu, Ping, Xue, Jinghua, Xu, Liangxiong, Li, Hanxiang, Wei, Xiaoyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223045/
https://www.ncbi.nlm.nih.gov/pubmed/31949315
http://dx.doi.org/10.1038/s41429-020-0277-6
_version_ 1783533692248915968
author Yang, Li
Li, Xiaoxia
Wu, Ping
Xue, Jinghua
Xu, Liangxiong
Li, Hanxiang
Wei, Xiaoyi
author_facet Yang, Li
Li, Xiaoxia
Wu, Ping
Xue, Jinghua
Xu, Liangxiong
Li, Hanxiang
Wei, Xiaoyi
author_sort Yang, Li
collection PubMed
description Eight new fasamycin-type polyketides, streptovertimycins A–H (1−8), were isolated from soil-derived Streptomyces morookaense SC1169 cultivated on wheat grains. Their structures were established by extensive spectroscopic analysis and theoretical computations of ECD spectra. Compounds 1−8 have a fasamycin-type pentacyclic structure featuring a 15-O-methyl group. They exhibited potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) with MIC values in the range of 0.63–5.0 μg/ml. The activity profile provided new insights into the structure–activity relationships of fasamycin-type antibiotics.
format Online
Article
Text
id pubmed-7223045
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-72230452020-05-15 Streptovertimycins A–H, new fasamycin-type antibiotics produced by a soil-derived Streptomyces morookaense strain Yang, Li Li, Xiaoxia Wu, Ping Xue, Jinghua Xu, Liangxiong Li, Hanxiang Wei, Xiaoyi J Antibiot (Tokyo) Article Eight new fasamycin-type polyketides, streptovertimycins A–H (1−8), were isolated from soil-derived Streptomyces morookaense SC1169 cultivated on wheat grains. Their structures were established by extensive spectroscopic analysis and theoretical computations of ECD spectra. Compounds 1−8 have a fasamycin-type pentacyclic structure featuring a 15-O-methyl group. They exhibited potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) with MIC values in the range of 0.63–5.0 μg/ml. The activity profile provided new insights into the structure–activity relationships of fasamycin-type antibiotics. Nature Publishing Group UK 2020-01-17 2020 /pmc/articles/PMC7223045/ /pubmed/31949315 http://dx.doi.org/10.1038/s41429-020-0277-6 Text en © The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Yang, Li
Li, Xiaoxia
Wu, Ping
Xue, Jinghua
Xu, Liangxiong
Li, Hanxiang
Wei, Xiaoyi
Streptovertimycins A–H, new fasamycin-type antibiotics produced by a soil-derived Streptomyces morookaense strain
title Streptovertimycins A–H, new fasamycin-type antibiotics produced by a soil-derived Streptomyces morookaense strain
title_full Streptovertimycins A–H, new fasamycin-type antibiotics produced by a soil-derived Streptomyces morookaense strain
title_fullStr Streptovertimycins A–H, new fasamycin-type antibiotics produced by a soil-derived Streptomyces morookaense strain
title_full_unstemmed Streptovertimycins A–H, new fasamycin-type antibiotics produced by a soil-derived Streptomyces morookaense strain
title_short Streptovertimycins A–H, new fasamycin-type antibiotics produced by a soil-derived Streptomyces morookaense strain
title_sort streptovertimycins a–h, new fasamycin-type antibiotics produced by a soil-derived streptomyces morookaense strain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223045/
https://www.ncbi.nlm.nih.gov/pubmed/31949315
http://dx.doi.org/10.1038/s41429-020-0277-6
work_keys_str_mv AT yangli streptovertimycinsahnewfasamycintypeantibioticsproducedbyasoilderivedstreptomycesmorookaensestrain
AT lixiaoxia streptovertimycinsahnewfasamycintypeantibioticsproducedbyasoilderivedstreptomycesmorookaensestrain
AT wuping streptovertimycinsahnewfasamycintypeantibioticsproducedbyasoilderivedstreptomycesmorookaensestrain
AT xuejinghua streptovertimycinsahnewfasamycintypeantibioticsproducedbyasoilderivedstreptomycesmorookaensestrain
AT xuliangxiong streptovertimycinsahnewfasamycintypeantibioticsproducedbyasoilderivedstreptomycesmorookaensestrain
AT lihanxiang streptovertimycinsahnewfasamycintypeantibioticsproducedbyasoilderivedstreptomycesmorookaensestrain
AT weixiaoyi streptovertimycinsahnewfasamycintypeantibioticsproducedbyasoilderivedstreptomycesmorookaensestrain

Ejemplares similares