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Association between multiple symptoms and quality of life of paediatric patients with cancer in Brazil: a cross-sectional study

OBJECTIVES: To identify the association of multiple symptoms and clinical characteristics on quality of life (QoL) of paediatric patients with cancer. DESIGN: A descriptive, cross-sectional study. SETTING: South American Children’s Hospital for Cancer Treatment (Barretos, São Paulo, Brazil). PARTICI...

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Autores principales: de Andrade Cadamuro, Sandra, Onishi Franco, Julia, Paiva, Carlos Eduardo, de Oliveira, Marco Antonio, Sakamoto Ribeiro Paiva, Bianca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223154/
https://www.ncbi.nlm.nih.gov/pubmed/32376756
http://dx.doi.org/10.1136/bmjopen-2019-035844
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author de Andrade Cadamuro, Sandra
Onishi Franco, Julia
Paiva, Carlos Eduardo
de Oliveira, Marco Antonio
Sakamoto Ribeiro Paiva, Bianca
author_facet de Andrade Cadamuro, Sandra
Onishi Franco, Julia
Paiva, Carlos Eduardo
de Oliveira, Marco Antonio
Sakamoto Ribeiro Paiva, Bianca
author_sort de Andrade Cadamuro, Sandra
collection PubMed
description OBJECTIVES: To identify the association of multiple symptoms and clinical characteristics on quality of life (QoL) of paediatric patients with cancer. DESIGN: A descriptive, cross-sectional study. SETTING: South American Children’s Hospital for Cancer Treatment (Barretos, São Paulo, Brazil). PARTICIPANTS: A total of 157 participants, 116 paediatric patients, diagnosed with cancer, undergoing chemotherapy treatment, between 7 and 18 years of age and 41 proxies for patients between 2 and 6 years of age. PRIMARY OUTCOME MEASURES: The severity and prevalence ofsymptoms were identified through the use of a culturally adapted multi-symptomscreening tool, and the influence these symptoms, in association with clinicalcharacteristics, had on the QOL of Brazilian pediatric cancer patients wasassessed. RESULTS: Prevalent symptoms identified by all participants were ‘feeling tired’ (98, 62.4%), ‘feeling more or less hungry (do not feel like eating) than you usually do’ (96, 61.1%), ‘changes in taste (flavour of the food)’ (89, 56.7%), ‘throwing up or feeling like you may throw up’ (77, 49%) and ‘changes in how your body (visually) or face looks’ (72, 45.9%). The multivariate analysis for symptom severity as reported by proxies showed that surgery (OR 0.20, 95% CI 0.04 to 0.98, p=0.047) and time of diagnosis (OR 0.14, 95% CI 0.03 to 0.66, p=0.012) were associated with a decreased OR of high severity symptoms. An analysis of the clinical characteristics associated with Pediatric Quality of Life Inventory (PedsQL) demonstrated no significant effect on QoL in any of the domains evaluated. The association between Symptom Screening in Pediatrics Tool and PedsQL in the self-report version demonstrated a significant negative influence of all symptoms on the QoL. CONCLUSIONS: The prevalence of symptoms experienced among pediatric patients during treatment was high and significantly influenced all aspects of quality of life, especially in the emotional domain.
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spelling pubmed-72231542020-05-15 Association between multiple symptoms and quality of life of paediatric patients with cancer in Brazil: a cross-sectional study de Andrade Cadamuro, Sandra Onishi Franco, Julia Paiva, Carlos Eduardo de Oliveira, Marco Antonio Sakamoto Ribeiro Paiva, Bianca BMJ Open Oncology OBJECTIVES: To identify the association of multiple symptoms and clinical characteristics on quality of life (QoL) of paediatric patients with cancer. DESIGN: A descriptive, cross-sectional study. SETTING: South American Children’s Hospital for Cancer Treatment (Barretos, São Paulo, Brazil). PARTICIPANTS: A total of 157 participants, 116 paediatric patients, diagnosed with cancer, undergoing chemotherapy treatment, between 7 and 18 years of age and 41 proxies for patients between 2 and 6 years of age. PRIMARY OUTCOME MEASURES: The severity and prevalence ofsymptoms were identified through the use of a culturally adapted multi-symptomscreening tool, and the influence these symptoms, in association with clinicalcharacteristics, had on the QOL of Brazilian pediatric cancer patients wasassessed. RESULTS: Prevalent symptoms identified by all participants were ‘feeling tired’ (98, 62.4%), ‘feeling more or less hungry (do not feel like eating) than you usually do’ (96, 61.1%), ‘changes in taste (flavour of the food)’ (89, 56.7%), ‘throwing up or feeling like you may throw up’ (77, 49%) and ‘changes in how your body (visually) or face looks’ (72, 45.9%). The multivariate analysis for symptom severity as reported by proxies showed that surgery (OR 0.20, 95% CI 0.04 to 0.98, p=0.047) and time of diagnosis (OR 0.14, 95% CI 0.03 to 0.66, p=0.012) were associated with a decreased OR of high severity symptoms. An analysis of the clinical characteristics associated with Pediatric Quality of Life Inventory (PedsQL) demonstrated no significant effect on QoL in any of the domains evaluated. The association between Symptom Screening in Pediatrics Tool and PedsQL in the self-report version demonstrated a significant negative influence of all symptoms on the QoL. CONCLUSIONS: The prevalence of symptoms experienced among pediatric patients during treatment was high and significantly influenced all aspects of quality of life, especially in the emotional domain. BMJ Publishing Group 2020-05-05 /pmc/articles/PMC7223154/ /pubmed/32376756 http://dx.doi.org/10.1136/bmjopen-2019-035844 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Oncology
de Andrade Cadamuro, Sandra
Onishi Franco, Julia
Paiva, Carlos Eduardo
de Oliveira, Marco Antonio
Sakamoto Ribeiro Paiva, Bianca
Association between multiple symptoms and quality of life of paediatric patients with cancer in Brazil: a cross-sectional study
title Association between multiple symptoms and quality of life of paediatric patients with cancer in Brazil: a cross-sectional study
title_full Association between multiple symptoms and quality of life of paediatric patients with cancer in Brazil: a cross-sectional study
title_fullStr Association between multiple symptoms and quality of life of paediatric patients with cancer in Brazil: a cross-sectional study
title_full_unstemmed Association between multiple symptoms and quality of life of paediatric patients with cancer in Brazil: a cross-sectional study
title_short Association between multiple symptoms and quality of life of paediatric patients with cancer in Brazil: a cross-sectional study
title_sort association between multiple symptoms and quality of life of paediatric patients with cancer in brazil: a cross-sectional study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223154/
https://www.ncbi.nlm.nih.gov/pubmed/32376756
http://dx.doi.org/10.1136/bmjopen-2019-035844
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