Cargando…

Toxic epidermal necrolysis syndrome induced by tigecycline: a case report

A 56-year-old man diagnosed with non-Hodgkin’s lymphoma underwent autologous bone marrow transplantation. He was subsequently admitted to the hospital with fever, and his symptoms were initially controlled by multiple antibiotics, including tigecycline. He then developed a generalized body rash that...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Jiahui, Wu, Fangli, Luo, Dan, Li, Miaojing, Gou, Xinming, Xi, Jieying, Zhu, Huachao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223212/
https://www.ncbi.nlm.nih.gov/pubmed/32400243
http://dx.doi.org/10.1177/0300060520922416
_version_ 1783533718697148416
author Yang, Jiahui
Wu, Fangli
Luo, Dan
Li, Miaojing
Gou, Xinming
Xi, Jieying
Zhu, Huachao
author_facet Yang, Jiahui
Wu, Fangli
Luo, Dan
Li, Miaojing
Gou, Xinming
Xi, Jieying
Zhu, Huachao
author_sort Yang, Jiahui
collection PubMed
description A 56-year-old man diagnosed with non-Hodgkin’s lymphoma underwent autologous bone marrow transplantation. He was subsequently admitted to the hospital with fever, and his symptoms were initially controlled by multiple antibiotics, including tigecycline. He then developed a generalized body rash that improved after treatment with anti-allergy drugs and steroids. Furthermore, tigecycline treatment for a second time resulted in a severe skin reaction with systemic symptoms, suggesting toxic epidermal necrolysis syndrome (TEN). The patient was shown to have the slow-metabolizing cytochrome P450 2C19 allele, denoted CYP2C19*2. He was transferred to a laminar flow ward and given strict mucosal care, together with corticosteroids and intravenous immunoglobulin. He recovered after 3 weeks of treatment. Tigecycline-induced Stevens–Johnson syndrome (SJS)/TEN has rarely been reported in the Chinese population. However, our experience suggests that Asians are more likely to have adverse reactions to drugs metabolized by the cytochrome P450 enzyme. Early identification of drug reactions and immediate cessation of the suspected drug is essential. Additionally, a combined therapy scheme and a clean laminar flow environment may improve the cure rate of SJS/TEN.
format Online
Article
Text
id pubmed-7223212
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-72232122020-05-20 Toxic epidermal necrolysis syndrome induced by tigecycline: a case report Yang, Jiahui Wu, Fangli Luo, Dan Li, Miaojing Gou, Xinming Xi, Jieying Zhu, Huachao J Int Med Res Case Report A 56-year-old man diagnosed with non-Hodgkin’s lymphoma underwent autologous bone marrow transplantation. He was subsequently admitted to the hospital with fever, and his symptoms were initially controlled by multiple antibiotics, including tigecycline. He then developed a generalized body rash that improved after treatment with anti-allergy drugs and steroids. Furthermore, tigecycline treatment for a second time resulted in a severe skin reaction with systemic symptoms, suggesting toxic epidermal necrolysis syndrome (TEN). The patient was shown to have the slow-metabolizing cytochrome P450 2C19 allele, denoted CYP2C19*2. He was transferred to a laminar flow ward and given strict mucosal care, together with corticosteroids and intravenous immunoglobulin. He recovered after 3 weeks of treatment. Tigecycline-induced Stevens–Johnson syndrome (SJS)/TEN has rarely been reported in the Chinese population. However, our experience suggests that Asians are more likely to have adverse reactions to drugs metabolized by the cytochrome P450 enzyme. Early identification of drug reactions and immediate cessation of the suspected drug is essential. Additionally, a combined therapy scheme and a clean laminar flow environment may improve the cure rate of SJS/TEN. SAGE Publications 2020-05-13 /pmc/articles/PMC7223212/ /pubmed/32400243 http://dx.doi.org/10.1177/0300060520922416 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Yang, Jiahui
Wu, Fangli
Luo, Dan
Li, Miaojing
Gou, Xinming
Xi, Jieying
Zhu, Huachao
Toxic epidermal necrolysis syndrome induced by tigecycline: a case report
title Toxic epidermal necrolysis syndrome induced by tigecycline: a case report
title_full Toxic epidermal necrolysis syndrome induced by tigecycline: a case report
title_fullStr Toxic epidermal necrolysis syndrome induced by tigecycline: a case report
title_full_unstemmed Toxic epidermal necrolysis syndrome induced by tigecycline: a case report
title_short Toxic epidermal necrolysis syndrome induced by tigecycline: a case report
title_sort toxic epidermal necrolysis syndrome induced by tigecycline: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223212/
https://www.ncbi.nlm.nih.gov/pubmed/32400243
http://dx.doi.org/10.1177/0300060520922416
work_keys_str_mv AT yangjiahui toxicepidermalnecrolysissyndromeinducedbytigecyclineacasereport
AT wufangli toxicepidermalnecrolysissyndromeinducedbytigecyclineacasereport
AT luodan toxicepidermalnecrolysissyndromeinducedbytigecyclineacasereport
AT limiaojing toxicepidermalnecrolysissyndromeinducedbytigecyclineacasereport
AT gouxinming toxicepidermalnecrolysissyndromeinducedbytigecyclineacasereport
AT xijieying toxicepidermalnecrolysissyndromeinducedbytigecyclineacasereport
AT zhuhuachao toxicepidermalnecrolysissyndromeinducedbytigecyclineacasereport