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Toxic epidermal necrolysis syndrome induced by tigecycline: a case report
A 56-year-old man diagnosed with non-Hodgkin’s lymphoma underwent autologous bone marrow transplantation. He was subsequently admitted to the hospital with fever, and his symptoms were initially controlled by multiple antibiotics, including tigecycline. He then developed a generalized body rash that...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223212/ https://www.ncbi.nlm.nih.gov/pubmed/32400243 http://dx.doi.org/10.1177/0300060520922416 |
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author | Yang, Jiahui Wu, Fangli Luo, Dan Li, Miaojing Gou, Xinming Xi, Jieying Zhu, Huachao |
author_facet | Yang, Jiahui Wu, Fangli Luo, Dan Li, Miaojing Gou, Xinming Xi, Jieying Zhu, Huachao |
author_sort | Yang, Jiahui |
collection | PubMed |
description | A 56-year-old man diagnosed with non-Hodgkin’s lymphoma underwent autologous bone marrow transplantation. He was subsequently admitted to the hospital with fever, and his symptoms were initially controlled by multiple antibiotics, including tigecycline. He then developed a generalized body rash that improved after treatment with anti-allergy drugs and steroids. Furthermore, tigecycline treatment for a second time resulted in a severe skin reaction with systemic symptoms, suggesting toxic epidermal necrolysis syndrome (TEN). The patient was shown to have the slow-metabolizing cytochrome P450 2C19 allele, denoted CYP2C19*2. He was transferred to a laminar flow ward and given strict mucosal care, together with corticosteroids and intravenous immunoglobulin. He recovered after 3 weeks of treatment. Tigecycline-induced Stevens–Johnson syndrome (SJS)/TEN has rarely been reported in the Chinese population. However, our experience suggests that Asians are more likely to have adverse reactions to drugs metabolized by the cytochrome P450 enzyme. Early identification of drug reactions and immediate cessation of the suspected drug is essential. Additionally, a combined therapy scheme and a clean laminar flow environment may improve the cure rate of SJS/TEN. |
format | Online Article Text |
id | pubmed-7223212 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-72232122020-05-20 Toxic epidermal necrolysis syndrome induced by tigecycline: a case report Yang, Jiahui Wu, Fangli Luo, Dan Li, Miaojing Gou, Xinming Xi, Jieying Zhu, Huachao J Int Med Res Case Report A 56-year-old man diagnosed with non-Hodgkin’s lymphoma underwent autologous bone marrow transplantation. He was subsequently admitted to the hospital with fever, and his symptoms were initially controlled by multiple antibiotics, including tigecycline. He then developed a generalized body rash that improved after treatment with anti-allergy drugs and steroids. Furthermore, tigecycline treatment for a second time resulted in a severe skin reaction with systemic symptoms, suggesting toxic epidermal necrolysis syndrome (TEN). The patient was shown to have the slow-metabolizing cytochrome P450 2C19 allele, denoted CYP2C19*2. He was transferred to a laminar flow ward and given strict mucosal care, together with corticosteroids and intravenous immunoglobulin. He recovered after 3 weeks of treatment. Tigecycline-induced Stevens–Johnson syndrome (SJS)/TEN has rarely been reported in the Chinese population. However, our experience suggests that Asians are more likely to have adverse reactions to drugs metabolized by the cytochrome P450 enzyme. Early identification of drug reactions and immediate cessation of the suspected drug is essential. Additionally, a combined therapy scheme and a clean laminar flow environment may improve the cure rate of SJS/TEN. SAGE Publications 2020-05-13 /pmc/articles/PMC7223212/ /pubmed/32400243 http://dx.doi.org/10.1177/0300060520922416 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Yang, Jiahui Wu, Fangli Luo, Dan Li, Miaojing Gou, Xinming Xi, Jieying Zhu, Huachao Toxic epidermal necrolysis syndrome induced by tigecycline: a case report |
title | Toxic epidermal necrolysis syndrome induced by tigecycline: a case report |
title_full | Toxic epidermal necrolysis syndrome induced by tigecycline: a case report |
title_fullStr | Toxic epidermal necrolysis syndrome induced by tigecycline: a case report |
title_full_unstemmed | Toxic epidermal necrolysis syndrome induced by tigecycline: a case report |
title_short | Toxic epidermal necrolysis syndrome induced by tigecycline: a case report |
title_sort | toxic epidermal necrolysis syndrome induced by tigecycline: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223212/ https://www.ncbi.nlm.nih.gov/pubmed/32400243 http://dx.doi.org/10.1177/0300060520922416 |
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