RAD52 variants influence NSCLC risk in the Chinese population in a high altitude area

BACKGROUND: Non-small cell lung cancer (NSCLC) accounts for approximately 80% of diagnosed lung cancer patients. RAD52 has been reported to be associated with the development of squamous cell lung carcinoma. In this study, we assessed the relationships of RAD52 genetic polymorphisms and NSCLC risk among the Chinese population at high altitude. METHODS: Eight single nucleotide polymorphisms (SNPs) of RAD52 were genotyped in the Agena MassARRAY platform among 506 NSCLC patients and 510 healthy controls. We examined the association of RAD52 polymorphisms with NSCLC risk using odds ratios (ORs) and 95% confidence intervals (CIs) via multiple genetic models. RESULTS: The rs10774474 A allele was related to a decreased risk of NSCLC in a high altitude population of China (OR = 0.82, 95% CI = 0.69–0.98, p = 0.032), whereas mutant alleles of rs1051672, rs7310449, rs1051669, rs6413436, rs4766377 and rs10849605 significantly increased NSCLC risk. Haplotype analysis showed that four haplotypes of RAD52 polymorphisms conferred an enhanced susceptibility to NSCLC (A(rs1051672)G(rs7310449)T(rs1051669)A(rs6413436): OR = 1.29, p = 0.021; G(rs1051672)A(rs7310449)C(rs1051669)G(rs6413436): OR = 1.21, p = 0.027; G(rs4766377)C(rs12822733)T(rs10774474)C(rs10849605): OR = 1.26, p = 0.032; A(rs4766377)C(rs12822733)A(rs10774474)T(rs10849605): OR = 1.21, p = 0.032). CONCLUSIONS: Our findings suggested the remarkable association of RAD52 polymorphisms with NSCLC risk among the Chinese population in a high altitude area. The reviews of this paper are available via the supplemental material section.