Identifying small-effect genetic associations overlooked by the conventional fixed-effect model in a large-scale meta-analysis of coronary artery disease

MOTIVATION: Common small-effect genetic variants that contribute to human complex traits and disease are typically identified using traditional fixed-effect (FE) meta-analysis methods. However, the power to detect genetic associations under FE models deteriorates with increasing heterogeneity, so th...

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Detalles Bibliográficos
Autores principales: Magosi, Lerato E, Goel, Anuj, Hopewell, Jemma C, Farrall, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223261/
https://www.ncbi.nlm.nih.gov/pubmed/31350884
http://dx.doi.org/10.1093/bioinformatics/btz590

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