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Cognitive Function in Liver Transplantation

PURPOSE OF REVIEW: Liver transplantation (LT) remains the only way to cure patients with severe liver diseases. Important questions about neurological sequelae and quality of life after LT have emerged. In this review, we discuss the neurocognitive changes associated with LT and we conclude with rec...

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Detalles Bibliográficos
Autores principales: Albhaisi, Somaya A. M., Bajaj, Jasmohan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223312/
https://www.ncbi.nlm.nih.gov/pubmed/32435574
http://dx.doi.org/10.1007/s40472-020-00274-2
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author Albhaisi, Somaya A. M.
Bajaj, Jasmohan S.
author_facet Albhaisi, Somaya A. M.
Bajaj, Jasmohan S.
author_sort Albhaisi, Somaya A. M.
collection PubMed
description PURPOSE OF REVIEW: Liver transplantation (LT) remains the only way to cure patients with severe liver diseases. Important questions about neurological sequelae and quality of life after LT have emerged. In this review, we discuss the neurocognitive changes associated with LT and we conclude with recommendations in this regard for patients, caregivers, and physicians. RECENT FINDINGS: Compared with other solid organ recipients, LT patients tend to have a higher incidence (up to 30%) of neurological complications post-LT. Even in absence of previous episodes of hepatic encephalopathy (HE), some patients display new onset of neurological symptoms post-LT, raising the concern about the role of other factors that may have a direct impact on cognitive function. SUMMARY: Different mechanisms have been postulated to explain these postoperative neurological symptoms. They include sequelae of HE, persistent impairment of cognitive function due to cirrhosis, or postoperative decompensation of an unknown or undiagnosed neurodegenerative disorder.
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spelling pubmed-72233122020-05-15 Cognitive Function in Liver Transplantation Albhaisi, Somaya A. M. Bajaj, Jasmohan S. Curr Transplant Rep Frailty and Gerontology (M. McAdams-DeMarco, Section Editor) PURPOSE OF REVIEW: Liver transplantation (LT) remains the only way to cure patients with severe liver diseases. Important questions about neurological sequelae and quality of life after LT have emerged. In this review, we discuss the neurocognitive changes associated with LT and we conclude with recommendations in this regard for patients, caregivers, and physicians. RECENT FINDINGS: Compared with other solid organ recipients, LT patients tend to have a higher incidence (up to 30%) of neurological complications post-LT. Even in absence of previous episodes of hepatic encephalopathy (HE), some patients display new onset of neurological symptoms post-LT, raising the concern about the role of other factors that may have a direct impact on cognitive function. SUMMARY: Different mechanisms have been postulated to explain these postoperative neurological symptoms. They include sequelae of HE, persistent impairment of cognitive function due to cirrhosis, or postoperative decompensation of an unknown or undiagnosed neurodegenerative disorder. Springer International Publishing 2020-03-26 2020 /pmc/articles/PMC7223312/ /pubmed/32435574 http://dx.doi.org/10.1007/s40472-020-00274-2 Text en © Springer Nature Switzerland AG 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Frailty and Gerontology (M. McAdams-DeMarco, Section Editor)
Albhaisi, Somaya A. M.
Bajaj, Jasmohan S.
Cognitive Function in Liver Transplantation
title Cognitive Function in Liver Transplantation
title_full Cognitive Function in Liver Transplantation
title_fullStr Cognitive Function in Liver Transplantation
title_full_unstemmed Cognitive Function in Liver Transplantation
title_short Cognitive Function in Liver Transplantation
title_sort cognitive function in liver transplantation
topic Frailty and Gerontology (M. McAdams-DeMarco, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223312/
https://www.ncbi.nlm.nih.gov/pubmed/32435574
http://dx.doi.org/10.1007/s40472-020-00274-2
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