Prostaglandin E(2) in a TLR3- and 7/8-agonist-based DC maturation cocktail generates mature, cytokine-producing, migratory DCs but impairs antigen cross-presentation to CD8(+) T cells

Mature dendritic cells (DCs) represent cellular adjuvants for optimal antigen presentation in cancer vaccines. Recently, a combination of prostaglandin E(2) (PGE(2)) with Toll-like receptor agonists (TLR-P) was proposed as a new standard to generate superior cytokine-producing DCs with high migrator...

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Detalles Bibliográficos
Autores principales: Gierlich, Philipp, Lex, Veronika, Technau, Antje, Keupp, Anne, Morper, Lorenz, Glunz, Amelie, Sennholz, Hanno, Rachor, Johannes, Sauer, Sascha, Marcu, Ana, Grigoleit, Götz Ulrich, Wölfl, Matthias, Schlegel, Paul G., Eyrich, Matthias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223547/
https://www.ncbi.nlm.nih.gov/pubmed/32100075
http://dx.doi.org/10.1007/s00262-019-02470-1

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