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A model of respiratory syncytial virus (RSV) infection of infants in newborn lambs
Many animal models have been established for respiratory syncytial virus (RSV) infection of infants with the purpose of studying the pathogenesis, immunological response, and pharmaceutical testing and the objective of finding novel therapies and preventive measures. This review centers on a neonata...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223741/ https://www.ncbi.nlm.nih.gov/pubmed/32347384 http://dx.doi.org/10.1007/s00441-020-03213-w |
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author | Sitthicharoenchai, Panchan Alnajjar, Sarhad Ackermann, Mark R. |
author_facet | Sitthicharoenchai, Panchan Alnajjar, Sarhad Ackermann, Mark R. |
author_sort | Sitthicharoenchai, Panchan |
collection | PubMed |
description | Many animal models have been established for respiratory syncytial virus (RSV) infection of infants with the purpose of studying the pathogenesis, immunological response, and pharmaceutical testing and the objective of finding novel therapies and preventive measures. This review centers on a neonatal lamb model of RSV infection that has similarities to RSV infection of infants. It includes a comprehensive description of anatomical and immunological similarities between ovine and human lungs along with comparison of pulmonary changes and immune responses with RSV infection. These features make the newborn lamb an effective model for investigating key aspects of RSV infection in infants. The importance of RSV lamb model application in preclinical therapeutic trials and current updates on new studies with the RSV-infected neonatal lamb are also highlighted. |
format | Online Article Text |
id | pubmed-7223741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-72237412020-05-15 A model of respiratory syncytial virus (RSV) infection of infants in newborn lambs Sitthicharoenchai, Panchan Alnajjar, Sarhad Ackermann, Mark R. Cell Tissue Res Review Many animal models have been established for respiratory syncytial virus (RSV) infection of infants with the purpose of studying the pathogenesis, immunological response, and pharmaceutical testing and the objective of finding novel therapies and preventive measures. This review centers on a neonatal lamb model of RSV infection that has similarities to RSV infection of infants. It includes a comprehensive description of anatomical and immunological similarities between ovine and human lungs along with comparison of pulmonary changes and immune responses with RSV infection. These features make the newborn lamb an effective model for investigating key aspects of RSV infection in infants. The importance of RSV lamb model application in preclinical therapeutic trials and current updates on new studies with the RSV-infected neonatal lamb are also highlighted. Springer Berlin Heidelberg 2020-04-29 2020 /pmc/articles/PMC7223741/ /pubmed/32347384 http://dx.doi.org/10.1007/s00441-020-03213-w Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Review Sitthicharoenchai, Panchan Alnajjar, Sarhad Ackermann, Mark R. A model of respiratory syncytial virus (RSV) infection of infants in newborn lambs |
title | A model of respiratory syncytial virus (RSV) infection of infants in newborn lambs |
title_full | A model of respiratory syncytial virus (RSV) infection of infants in newborn lambs |
title_fullStr | A model of respiratory syncytial virus (RSV) infection of infants in newborn lambs |
title_full_unstemmed | A model of respiratory syncytial virus (RSV) infection of infants in newborn lambs |
title_short | A model of respiratory syncytial virus (RSV) infection of infants in newborn lambs |
title_sort | model of respiratory syncytial virus (rsv) infection of infants in newborn lambs |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223741/ https://www.ncbi.nlm.nih.gov/pubmed/32347384 http://dx.doi.org/10.1007/s00441-020-03213-w |
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