Cargando…

Acute kidney injury in hospitalized children: consequences and outcomes

Over the past decade, the nephrology and critical care communities have adopted a consensus approach to diagnosing acute kidney injury (AKI) and, as a result, we have seen transformative changes in our understanding of pediatric AKI epidemiology. The data regarding outcomes among neonates and childr...

Descripción completa

Detalles Bibliográficos
Autores principales: Uber, Amanda M., Sutherland, Scott M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223774/
https://www.ncbi.nlm.nih.gov/pubmed/30386936
http://dx.doi.org/10.1007/s00467-018-4128-7
_version_ 1783533792643776512
author Uber, Amanda M.
Sutherland, Scott M.
author_facet Uber, Amanda M.
Sutherland, Scott M.
author_sort Uber, Amanda M.
collection PubMed
description Over the past decade, the nephrology and critical care communities have adopted a consensus approach to diagnosing acute kidney injury (AKI) and, as a result, we have seen transformative changes in our understanding of pediatric AKI epidemiology. The data regarding outcomes among neonates and children who develop AKI have become far more robust and AKI has been clearly linked with an increased need for mechanical ventilation, longer inpatient stays, and higher mortality. Though AKI was historically thought to be self-limited, we now know that renal recovery is far from universal, particularly when AKI is severe; the absence of recovery from AKI also carries longitudinal prognostic implications. AKI survivors, especially those without full recovery, are at risk for chronic renal sequelae including proteinuria, hypertension, and chronic kidney disease. This review comprehensively describes AKI-related outcomes across the entire pediatric age spectrum, using the most rigorous studies to identify the independent effects of AKI events.
format Online
Article
Text
id pubmed-7223774
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-72237742020-05-15 Acute kidney injury in hospitalized children: consequences and outcomes Uber, Amanda M. Sutherland, Scott M. Pediatr Nephrol Educational Review Over the past decade, the nephrology and critical care communities have adopted a consensus approach to diagnosing acute kidney injury (AKI) and, as a result, we have seen transformative changes in our understanding of pediatric AKI epidemiology. The data regarding outcomes among neonates and children who develop AKI have become far more robust and AKI has been clearly linked with an increased need for mechanical ventilation, longer inpatient stays, and higher mortality. Though AKI was historically thought to be self-limited, we now know that renal recovery is far from universal, particularly when AKI is severe; the absence of recovery from AKI also carries longitudinal prognostic implications. AKI survivors, especially those without full recovery, are at risk for chronic renal sequelae including proteinuria, hypertension, and chronic kidney disease. This review comprehensively describes AKI-related outcomes across the entire pediatric age spectrum, using the most rigorous studies to identify the independent effects of AKI events. Springer Berlin Heidelberg 2018-11-01 2020 /pmc/articles/PMC7223774/ /pubmed/30386936 http://dx.doi.org/10.1007/s00467-018-4128-7 Text en © IPNA 2018 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Educational Review
Uber, Amanda M.
Sutherland, Scott M.
Acute kidney injury in hospitalized children: consequences and outcomes
title Acute kidney injury in hospitalized children: consequences and outcomes
title_full Acute kidney injury in hospitalized children: consequences and outcomes
title_fullStr Acute kidney injury in hospitalized children: consequences and outcomes
title_full_unstemmed Acute kidney injury in hospitalized children: consequences and outcomes
title_short Acute kidney injury in hospitalized children: consequences and outcomes
title_sort acute kidney injury in hospitalized children: consequences and outcomes
topic Educational Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223774/
https://www.ncbi.nlm.nih.gov/pubmed/30386936
http://dx.doi.org/10.1007/s00467-018-4128-7
work_keys_str_mv AT uberamandam acutekidneyinjuryinhospitalizedchildrenconsequencesandoutcomes
AT sutherlandscottm acutekidneyinjuryinhospitalizedchildrenconsequencesandoutcomes