Genetic characterization of a novel recombinant echovirus 30 strain causing a regional epidemic of aseptic meningitis in Hokkaido, Japan, 2017

A regional epidemic of aseptic meningitis caused by echovirus 30 (E30) occurred in Hokkaido, Japan, during the period of August-December 2017. To investigate their phylogenetic relationship to other human enteroviruses, we determined the complete genomic nucleotide sequences of isolates from this ou...

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Autores principales: Miyoshi, Masahiro, Goto, Akiko, Komagome, Rika, Yamaguchi, Hiroki, Maruo, Yuji, Nakanishi, Masanori, Ishida, Setsuko, Nagano, Hideki, Sugisawa, Takahisa, Okano, Motohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223842/
https://www.ncbi.nlm.nih.gov/pubmed/31828510
http://dx.doi.org/10.1007/s00705-019-04484-7
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author Miyoshi, Masahiro
Goto, Akiko
Komagome, Rika
Yamaguchi, Hiroki
Maruo, Yuji
Nakanishi, Masanori
Ishida, Setsuko
Nagano, Hideki
Sugisawa, Takahisa
Okano, Motohiko
author_facet Miyoshi, Masahiro
Goto, Akiko
Komagome, Rika
Yamaguchi, Hiroki
Maruo, Yuji
Nakanishi, Masanori
Ishida, Setsuko
Nagano, Hideki
Sugisawa, Takahisa
Okano, Motohiko
author_sort Miyoshi, Masahiro
collection PubMed
description A regional epidemic of aseptic meningitis caused by echovirus 30 (E30) occurred in Hokkaido, Japan, during the period of August-December 2017. To investigate their phylogenetic relationship to other human enteroviruses, we determined the complete genomic nucleotide sequences of isolates from this outbreak. Phylogenetic analysis of the viral capsid protein 1 gene showed that the strains were most closely related to E30 strains detected in Germany, France, and Russia in 2013. In contrast, the region encoding the viral protease and the RNA-dependent RNA polymerase had a close phylogenetic relationship to non-E30 enteroviruses detected in the United Kingdom and Switzerland in 2015-2017, suggesting that a recombination event had occurred. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00705-019-04484-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-72238422020-05-15 Genetic characterization of a novel recombinant echovirus 30 strain causing a regional epidemic of aseptic meningitis in Hokkaido, Japan, 2017 Miyoshi, Masahiro Goto, Akiko Komagome, Rika Yamaguchi, Hiroki Maruo, Yuji Nakanishi, Masanori Ishida, Setsuko Nagano, Hideki Sugisawa, Takahisa Okano, Motohiko Arch Virol Brief Report A regional epidemic of aseptic meningitis caused by echovirus 30 (E30) occurred in Hokkaido, Japan, during the period of August-December 2017. To investigate their phylogenetic relationship to other human enteroviruses, we determined the complete genomic nucleotide sequences of isolates from this outbreak. Phylogenetic analysis of the viral capsid protein 1 gene showed that the strains were most closely related to E30 strains detected in Germany, France, and Russia in 2013. In contrast, the region encoding the viral protease and the RNA-dependent RNA polymerase had a close phylogenetic relationship to non-E30 enteroviruses detected in the United Kingdom and Switzerland in 2015-2017, suggesting that a recombination event had occurred. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00705-019-04484-7) contains supplementary material, which is available to authorized users. Springer Vienna 2019-12-11 2020 /pmc/articles/PMC7223842/ /pubmed/31828510 http://dx.doi.org/10.1007/s00705-019-04484-7 Text en © Springer-Verlag GmbH Austria, part of Springer Nature 2019 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Miyoshi, Masahiro
Goto, Akiko
Komagome, Rika
Yamaguchi, Hiroki
Maruo, Yuji
Nakanishi, Masanori
Ishida, Setsuko
Nagano, Hideki
Sugisawa, Takahisa
Okano, Motohiko
Genetic characterization of a novel recombinant echovirus 30 strain causing a regional epidemic of aseptic meningitis in Hokkaido, Japan, 2017
title Genetic characterization of a novel recombinant echovirus 30 strain causing a regional epidemic of aseptic meningitis in Hokkaido, Japan, 2017
title_full Genetic characterization of a novel recombinant echovirus 30 strain causing a regional epidemic of aseptic meningitis in Hokkaido, Japan, 2017
title_fullStr Genetic characterization of a novel recombinant echovirus 30 strain causing a regional epidemic of aseptic meningitis in Hokkaido, Japan, 2017
title_full_unstemmed Genetic characterization of a novel recombinant echovirus 30 strain causing a regional epidemic of aseptic meningitis in Hokkaido, Japan, 2017
title_short Genetic characterization of a novel recombinant echovirus 30 strain causing a regional epidemic of aseptic meningitis in Hokkaido, Japan, 2017
title_sort genetic characterization of a novel recombinant echovirus 30 strain causing a regional epidemic of aseptic meningitis in hokkaido, japan, 2017
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223842/
https://www.ncbi.nlm.nih.gov/pubmed/31828510
http://dx.doi.org/10.1007/s00705-019-04484-7
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