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Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience

OBJECTIVE: Evaluate renal outcomes and early predictive factors in infants with congenital posterior urethral valves who required catheter or surgical urinary tract decompression within the first 7 days of life. STUDY DESIGN: A 10-year retrospective study at a single hospital. Primary outcomes were...

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Autores principales: Coquillette, Madeline, Lee, Richard S., Pagni, Sarah E., Cataltepe, Sule, Stein, Deborah R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223871/
https://www.ncbi.nlm.nih.gov/pubmed/31471579
http://dx.doi.org/10.1038/s41372-019-0489-4
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author Coquillette, Madeline
Lee, Richard S.
Pagni, Sarah E.
Cataltepe, Sule
Stein, Deborah R.
author_facet Coquillette, Madeline
Lee, Richard S.
Pagni, Sarah E.
Cataltepe, Sule
Stein, Deborah R.
author_sort Coquillette, Madeline
collection PubMed
description OBJECTIVE: Evaluate renal outcomes and early predictive factors in infants with congenital posterior urethral valves who required catheter or surgical urinary tract decompression within the first 7 days of life. STUDY DESIGN: A 10-year retrospective study at a single hospital. Primary outcomes were estimated glomerular filtration rate (eGFR) and development of end stage renal disease (ESRD). RESULTS: Of 35 infants, 50% developed eGFR <90 mL/min/1.73 m(2) and 15% progressed to ESRD. Nadir creatinine, need for invasive ventilation in the newborn period, and need for surgical diversion after catheter diversion were associated with worse outcomes. 50% of infants requiring invasive ventilation as neonates developed eGFR <60 mL/min/1.73 m(2) in childhood. CONCLUSIONS: Half of infants with early presentation and intervention developed significant renal insufficiency in childhood, similar to children with later presentation or who had fetal intervention. Invasive ventilation in the newborn period and need for surgical urinary diversion are associated with worse outcomes.
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spelling pubmed-72238712020-05-15 Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience Coquillette, Madeline Lee, Richard S. Pagni, Sarah E. Cataltepe, Sule Stein, Deborah R. J Perinatol Article OBJECTIVE: Evaluate renal outcomes and early predictive factors in infants with congenital posterior urethral valves who required catheter or surgical urinary tract decompression within the first 7 days of life. STUDY DESIGN: A 10-year retrospective study at a single hospital. Primary outcomes were estimated glomerular filtration rate (eGFR) and development of end stage renal disease (ESRD). RESULTS: Of 35 infants, 50% developed eGFR <90 mL/min/1.73 m(2) and 15% progressed to ESRD. Nadir creatinine, need for invasive ventilation in the newborn period, and need for surgical diversion after catheter diversion were associated with worse outcomes. 50% of infants requiring invasive ventilation as neonates developed eGFR <60 mL/min/1.73 m(2) in childhood. CONCLUSIONS: Half of infants with early presentation and intervention developed significant renal insufficiency in childhood, similar to children with later presentation or who had fetal intervention. Invasive ventilation in the newborn period and need for surgical urinary diversion are associated with worse outcomes. Nature Publishing Group US 2019-08-30 2020 /pmc/articles/PMC7223871/ /pubmed/31471579 http://dx.doi.org/10.1038/s41372-019-0489-4 Text en © The Author(s), under exclusive licence to Springer Nature America, Inc. 2019 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Coquillette, Madeline
Lee, Richard S.
Pagni, Sarah E.
Cataltepe, Sule
Stein, Deborah R.
Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience
title Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience
title_full Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience
title_fullStr Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience
title_full_unstemmed Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience
title_short Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience
title_sort renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223871/
https://www.ncbi.nlm.nih.gov/pubmed/31471579
http://dx.doi.org/10.1038/s41372-019-0489-4
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