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Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience
OBJECTIVE: Evaluate renal outcomes and early predictive factors in infants with congenital posterior urethral valves who required catheter or surgical urinary tract decompression within the first 7 days of life. STUDY DESIGN: A 10-year retrospective study at a single hospital. Primary outcomes were...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223871/ https://www.ncbi.nlm.nih.gov/pubmed/31471579 http://dx.doi.org/10.1038/s41372-019-0489-4 |
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author | Coquillette, Madeline Lee, Richard S. Pagni, Sarah E. Cataltepe, Sule Stein, Deborah R. |
author_facet | Coquillette, Madeline Lee, Richard S. Pagni, Sarah E. Cataltepe, Sule Stein, Deborah R. |
author_sort | Coquillette, Madeline |
collection | PubMed |
description | OBJECTIVE: Evaluate renal outcomes and early predictive factors in infants with congenital posterior urethral valves who required catheter or surgical urinary tract decompression within the first 7 days of life. STUDY DESIGN: A 10-year retrospective study at a single hospital. Primary outcomes were estimated glomerular filtration rate (eGFR) and development of end stage renal disease (ESRD). RESULTS: Of 35 infants, 50% developed eGFR <90 mL/min/1.73 m(2) and 15% progressed to ESRD. Nadir creatinine, need for invasive ventilation in the newborn period, and need for surgical diversion after catheter diversion were associated with worse outcomes. 50% of infants requiring invasive ventilation as neonates developed eGFR <60 mL/min/1.73 m(2) in childhood. CONCLUSIONS: Half of infants with early presentation and intervention developed significant renal insufficiency in childhood, similar to children with later presentation or who had fetal intervention. Invasive ventilation in the newborn period and need for surgical urinary diversion are associated with worse outcomes. |
format | Online Article Text |
id | pubmed-7223871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-72238712020-05-15 Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience Coquillette, Madeline Lee, Richard S. Pagni, Sarah E. Cataltepe, Sule Stein, Deborah R. J Perinatol Article OBJECTIVE: Evaluate renal outcomes and early predictive factors in infants with congenital posterior urethral valves who required catheter or surgical urinary tract decompression within the first 7 days of life. STUDY DESIGN: A 10-year retrospective study at a single hospital. Primary outcomes were estimated glomerular filtration rate (eGFR) and development of end stage renal disease (ESRD). RESULTS: Of 35 infants, 50% developed eGFR <90 mL/min/1.73 m(2) and 15% progressed to ESRD. Nadir creatinine, need for invasive ventilation in the newborn period, and need for surgical diversion after catheter diversion were associated with worse outcomes. 50% of infants requiring invasive ventilation as neonates developed eGFR <60 mL/min/1.73 m(2) in childhood. CONCLUSIONS: Half of infants with early presentation and intervention developed significant renal insufficiency in childhood, similar to children with later presentation or who had fetal intervention. Invasive ventilation in the newborn period and need for surgical urinary diversion are associated with worse outcomes. Nature Publishing Group US 2019-08-30 2020 /pmc/articles/PMC7223871/ /pubmed/31471579 http://dx.doi.org/10.1038/s41372-019-0489-4 Text en © The Author(s), under exclusive licence to Springer Nature America, Inc. 2019 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Coquillette, Madeline Lee, Richard S. Pagni, Sarah E. Cataltepe, Sule Stein, Deborah R. Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience |
title | Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience |
title_full | Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience |
title_fullStr | Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience |
title_full_unstemmed | Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience |
title_short | Renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience |
title_sort | renal outcomes of neonates with early presentation of posterior urethral valves: a 10-year single center experience |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223871/ https://www.ncbi.nlm.nih.gov/pubmed/31471579 http://dx.doi.org/10.1038/s41372-019-0489-4 |
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