Hypercapnia Exacerbates the Blood–Brain Barrier Disruption Via Promoting HIF-1a Nuclear Translocation in the Astrocytes of the Hippocampus: Implication in Further Cognitive Impairment in Hypoxemic Adult Rats

Hypercapnia in combination with hypoxemia is usually present in severe respiratory disease in the intensive care unit (ICU) and can lead to more severe cognitive dysfunction. Increasing evidence has indicated that the compromised blood–brain barrier (BBB) in the hippocampus in hypoxemia conditions c...

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Detalles Bibliográficos
Autores principales: Liu, Xinqiang, Ding, Hongguang, Li, Xusheng, Deng, Yiyu, Liu, Xiaoyu, Wang, Kangrong, Wen, Miaoyun, Chen, Shenglong, Jiang, Wenqiang, Zeng, Hongke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224048/
https://www.ncbi.nlm.nih.gov/pubmed/32328929
http://dx.doi.org/10.1007/s11064-020-03038-7

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