Genotoxic stress triggers the activation of IRE1α-dependent RNA decay to modulate the DNA damage response

The molecular connections between homeostatic systems that maintain both genome integrity and proteostasis are poorly understood. Here we identify the selective activation of the unfolded protein response transducer IRE1α under genotoxic stress to modulate repair programs and sustain cell survival....

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Detalles Bibliográficos
Autores principales: Dufey, Estefanie, Bravo-San Pedro, José Manuel, Eggers, Cristian, González-Quiroz, Matías, Urra, Hery, Sagredo, Alfredo I., Sepulveda, Denisse, Pihán, Philippe, Carreras-Sureda, Amado, Hazari, Younis, Sagredo, Eduardo A., Gutierrez, Daniela, Valls, Cristian, Papaioannou, Alexandra, Acosta-Alvear, Diego, Campos, Gisela, Domingos, Pedro M., Pedeux, Rémy, Chevet, Eric, Alvarez, Alejandra, Godoy, Patricio, Walter, Peter, Glavic, Alvaro, Kroemer, Guido, Hetz, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224204/
https://www.ncbi.nlm.nih.gov/pubmed/32409639
http://dx.doi.org/10.1038/s41467-020-15694-y

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