Development of Small Molecule MEIS Inhibitors that modulate HSC activity

Meis1, which belongs to TALE-type class of homeobox gene family, appeared as one of the key regulators of hematopoietic stem cell (HSC) self-renewal and a potential therapeutical target. However, small molecule inhibitors of MEIS1 remained unknown. This led us to develop inhibitors of MEIS1 that cou...

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Detalles Bibliográficos
Autores principales: Turan, Raife Dilek, Albayrak, Esra, Uslu, Merve, Siyah, Pinar, Alyazici, Lamia Yazgi, Kalkan, Batuhan Mert, Aslan, Galip Servet, Yucel, Dogacan, Aksoz, Merve, Tuysuz, Emre Can, Meric, Neslihan, Durdagi, Serdar, Gulbas, Zafer, Kocabas, Fatih
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224207/
https://www.ncbi.nlm.nih.gov/pubmed/32409701
http://dx.doi.org/10.1038/s41598-020-64888-3

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