Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures

Despite high initial efficacy, targeted therapies eventually fail in advanced cancers, as tumors develop resistance and relapse. In contrast to the substantial body of research on the molecular mechanisms of resistance, understanding of how resistance evolves remains limited. Using an experimental m...

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Detalles Bibliográficos
Autores principales: Vander Velde, Robert, Yoon, Nara, Marusyk, Viktoriya, Durmaz, Arda, Dhawan, Andrew, Miroshnychenko, Daria, Lozano-Peral, Diego, Desai, Bina, Balynska, Olena, Poleszhuk, Jan, Kenian, Liu, Teng, Mingxiang, Abazeed, Mohamed, Mian, Omar, Tan, Aik Choon, Haura, Eric, Scott, Jacob, Marusyk, Andriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224215/
https://www.ncbi.nlm.nih.gov/pubmed/32409712
http://dx.doi.org/10.1038/s41467-020-16212-w

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