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Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education
Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224277/ https://www.ncbi.nlm.nih.gov/pubmed/32409744 http://dx.doi.org/10.1038/s41598-020-64883-8 |
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author | Jelenkovic, Aline Sund, Reijo Yokoyama, Yoshie Latvala, Antti Sugawara, Masumi Tanaka, Mami Matsumoto, Satoko Freitas, Duarte L. Maia, José Antonio Knafo-Noam, Ariel Mankuta, David Abramson, Lior Ji, Fuling Ning, Feng Pang, Zengchang Rebato, Esther Saudino, Kimberly J. Cutler, Tessa L. Hopper, John L. Ullemar, Vilhelmina Almqvist, Catarina Magnusson, Patrik K. E. Cozen, Wendy Hwang, Amie E. Mack, Thomas M. Nelson, Tracy L. Whitfield, Keith E. Sung, Joohon Kim, Jina Lee, Jooyeon Lee, Sooji Llewellyn, Clare H. Fisher, Abigail Medda, Emanuela Nisticò, Lorenza Toccaceli, Virgilia Baker, Laura A. Tuvblad, Catherine Corley, Robin P. Huibregtse, Brooke M. Derom, Catherine A. Vlietinck, Robert F. Loos, Ruth J. F. Burt, S. Alexandra Klump, Kelly L. Silberg, Judy L. Maes, Hermine H. Krueger, Robert F. McGue, Matt Pahlen, Shandell Gatz, Margaret Butler, David A. Harris, Jennifer R. Brandt, Ingunn Nilsen, Thomas S. Harden, K. Paige Tucker-Drob, Elliot M. Franz, Carol E. Kremen, William S. Lyons, Michael J. Lichtenstein, Paul Bartels, Meike Beijsterveldt, Catharina E. M. van Willemsen, Gonneke Öncel, Sevgi Y. Aliev, Fazil Jeong, Hoe-Uk Hur, Yoon-Mi Turkheimer, Eric Boomsma, Dorret I. Sørensen, Thorkild I. A. Kaprio, Jaakko Silventoinen, Karri |
author_facet | Jelenkovic, Aline Sund, Reijo Yokoyama, Yoshie Latvala, Antti Sugawara, Masumi Tanaka, Mami Matsumoto, Satoko Freitas, Duarte L. Maia, José Antonio Knafo-Noam, Ariel Mankuta, David Abramson, Lior Ji, Fuling Ning, Feng Pang, Zengchang Rebato, Esther Saudino, Kimberly J. Cutler, Tessa L. Hopper, John L. Ullemar, Vilhelmina Almqvist, Catarina Magnusson, Patrik K. E. Cozen, Wendy Hwang, Amie E. Mack, Thomas M. Nelson, Tracy L. Whitfield, Keith E. Sung, Joohon Kim, Jina Lee, Jooyeon Lee, Sooji Llewellyn, Clare H. Fisher, Abigail Medda, Emanuela Nisticò, Lorenza Toccaceli, Virgilia Baker, Laura A. Tuvblad, Catherine Corley, Robin P. Huibregtse, Brooke M. Derom, Catherine A. Vlietinck, Robert F. Loos, Ruth J. F. Burt, S. Alexandra Klump, Kelly L. Silberg, Judy L. Maes, Hermine H. Krueger, Robert F. McGue, Matt Pahlen, Shandell Gatz, Margaret Butler, David A. Harris, Jennifer R. Brandt, Ingunn Nilsen, Thomas S. Harden, K. Paige Tucker-Drob, Elliot M. Franz, Carol E. Kremen, William S. Lyons, Michael J. Lichtenstein, Paul Bartels, Meike Beijsterveldt, Catharina E. M. van Willemsen, Gonneke Öncel, Sevgi Y. Aliev, Fazil Jeong, Hoe-Uk Hur, Yoon-Mi Turkheimer, Eric Boomsma, Dorret I. Sørensen, Thorkild I. A. Kaprio, Jaakko Silventoinen, Karri |
author_sort | Jelenkovic, Aline |
collection | PubMed |
description | Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis. |
format | Online Article Text |
id | pubmed-7224277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-72242772020-05-20 Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education Jelenkovic, Aline Sund, Reijo Yokoyama, Yoshie Latvala, Antti Sugawara, Masumi Tanaka, Mami Matsumoto, Satoko Freitas, Duarte L. Maia, José Antonio Knafo-Noam, Ariel Mankuta, David Abramson, Lior Ji, Fuling Ning, Feng Pang, Zengchang Rebato, Esther Saudino, Kimberly J. Cutler, Tessa L. Hopper, John L. Ullemar, Vilhelmina Almqvist, Catarina Magnusson, Patrik K. E. Cozen, Wendy Hwang, Amie E. Mack, Thomas M. Nelson, Tracy L. Whitfield, Keith E. Sung, Joohon Kim, Jina Lee, Jooyeon Lee, Sooji Llewellyn, Clare H. Fisher, Abigail Medda, Emanuela Nisticò, Lorenza Toccaceli, Virgilia Baker, Laura A. Tuvblad, Catherine Corley, Robin P. Huibregtse, Brooke M. Derom, Catherine A. Vlietinck, Robert F. Loos, Ruth J. F. Burt, S. Alexandra Klump, Kelly L. Silberg, Judy L. Maes, Hermine H. Krueger, Robert F. McGue, Matt Pahlen, Shandell Gatz, Margaret Butler, David A. Harris, Jennifer R. Brandt, Ingunn Nilsen, Thomas S. Harden, K. Paige Tucker-Drob, Elliot M. Franz, Carol E. Kremen, William S. Lyons, Michael J. Lichtenstein, Paul Bartels, Meike Beijsterveldt, Catharina E. M. van Willemsen, Gonneke Öncel, Sevgi Y. Aliev, Fazil Jeong, Hoe-Uk Hur, Yoon-Mi Turkheimer, Eric Boomsma, Dorret I. Sørensen, Thorkild I. A. Kaprio, Jaakko Silventoinen, Karri Sci Rep Article Genetic factors explain a major proportion of human height variation, but differences in mean stature have also been found between socio-economic categories suggesting a possible effect of environment. By utilizing a classical twin design which allows decomposing the variation of height into genetic and environmental components, we tested the hypothesis that environmental variation in height is greater in offspring of lower educated parents. Twin data from 29 cohorts including 65,978 complete twin pairs with information on height at ages 1 to 69 years and on parental education were pooled allowing the analyses at different ages and in three geographic-cultural regions (Europe, North America and Australia, and East Asia). Parental education mostly showed a positive association with offspring height, with significant associations in mid-childhood and from adolescence onwards. In variance decomposition modeling, the genetic and environmental variance components of height did not show a consistent relation to parental education. A random-effects meta-regression analysis of the aggregate-level data showed a trend towards greater shared environmental variation of height in low parental education families. In conclusion, in our very large dataset from twin cohorts around the globe, these results provide only weak evidence for the study hypothesis. Nature Publishing Group UK 2020-05-14 /pmc/articles/PMC7224277/ /pubmed/32409744 http://dx.doi.org/10.1038/s41598-020-64883-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Jelenkovic, Aline Sund, Reijo Yokoyama, Yoshie Latvala, Antti Sugawara, Masumi Tanaka, Mami Matsumoto, Satoko Freitas, Duarte L. Maia, José Antonio Knafo-Noam, Ariel Mankuta, David Abramson, Lior Ji, Fuling Ning, Feng Pang, Zengchang Rebato, Esther Saudino, Kimberly J. Cutler, Tessa L. Hopper, John L. Ullemar, Vilhelmina Almqvist, Catarina Magnusson, Patrik K. E. Cozen, Wendy Hwang, Amie E. Mack, Thomas M. Nelson, Tracy L. Whitfield, Keith E. Sung, Joohon Kim, Jina Lee, Jooyeon Lee, Sooji Llewellyn, Clare H. Fisher, Abigail Medda, Emanuela Nisticò, Lorenza Toccaceli, Virgilia Baker, Laura A. Tuvblad, Catherine Corley, Robin P. Huibregtse, Brooke M. Derom, Catherine A. Vlietinck, Robert F. Loos, Ruth J. F. Burt, S. Alexandra Klump, Kelly L. Silberg, Judy L. Maes, Hermine H. Krueger, Robert F. McGue, Matt Pahlen, Shandell Gatz, Margaret Butler, David A. Harris, Jennifer R. Brandt, Ingunn Nilsen, Thomas S. Harden, K. Paige Tucker-Drob, Elliot M. Franz, Carol E. Kremen, William S. Lyons, Michael J. Lichtenstein, Paul Bartels, Meike Beijsterveldt, Catharina E. M. van Willemsen, Gonneke Öncel, Sevgi Y. Aliev, Fazil Jeong, Hoe-Uk Hur, Yoon-Mi Turkheimer, Eric Boomsma, Dorret I. Sørensen, Thorkild I. A. Kaprio, Jaakko Silventoinen, Karri Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education |
title | Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education |
title_full | Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education |
title_fullStr | Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education |
title_full_unstemmed | Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education |
title_short | Genetic and environmental influences on human height from infancy through adulthood at different levels of parental education |
title_sort | genetic and environmental influences on human height from infancy through adulthood at different levels of parental education |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224277/ https://www.ncbi.nlm.nih.gov/pubmed/32409744 http://dx.doi.org/10.1038/s41598-020-64883-8 |
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