Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery

Yap is the key component of Hippo pathway which plays crucial roles in tumorigenesis. Inhibition of Yap activity could promote apoptosis, suppress proliferation, and restrain metastasis of cancer cells. However, how Yap is regulated is not fully understood. Here, we reported Yap being negatively reg...

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Detalles Bibliográficos
Autores principales: Wu, Nan, Yuan, Zhidong, Du, Kevin Y., Fang, Ling, Lyu, Juanjuan, Zhang, Chao, He, Alina, Eshaghi, Esra, Zeng, Kaixuan, Ma, Jian, Du, William W., Yang, Burton B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224378/
https://www.ncbi.nlm.nih.gov/pubmed/31092884
http://dx.doi.org/10.1038/s41418-019-0337-2

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