DLX1008 (brolucizumab), a single-chain anti-VEGF-A antibody fragment with low picomolar affinity, leads to tumor involution in an in vivo model of Kaposi Sarcoma

Kaposi Sarcoma (KS) is among the most angiogenic cancers in humans and an AIDS-defining condition. KS-associated herpesvirus (KSHV) is necessary for KS development, as is vascular endothelial growth factor (VEGF-A). DLX1008 is a novel anti-VEGF-A antibody single-chain variable fragment (scFv) with l...

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Detalles Bibliográficos
Autores principales: Eason, Anthony B., Sin, Sang-Hoon, Shah, Mohsin, Yuan, Hong, Phillips, Douglas J., Droste, Miriam, Shamshiev, Abdijapar, Dittmer, Dirk P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224538/
https://www.ncbi.nlm.nih.gov/pubmed/32407363
http://dx.doi.org/10.1371/journal.pone.0233116

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