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A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels

Mechanical interactions between flowing and coagulated blood (thrombus) are crucial in dictating the deformation and remodeling of a thrombus after its formation in hemostasis. We propose a fully-Eulerian, three-dimensional, phase-field model of thrombus that is calibrated with existing in vitro exp...

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Autores principales: Zheng, Xiaoning, Yazdani, Alireza, Li, He, Humphrey, Jay D., Karniadakis, George E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224566/
https://www.ncbi.nlm.nih.gov/pubmed/32343724
http://dx.doi.org/10.1371/journal.pcbi.1007709
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author Zheng, Xiaoning
Yazdani, Alireza
Li, He
Humphrey, Jay D.
Karniadakis, George E.
author_facet Zheng, Xiaoning
Yazdani, Alireza
Li, He
Humphrey, Jay D.
Karniadakis, George E.
author_sort Zheng, Xiaoning
collection PubMed
description Mechanical interactions between flowing and coagulated blood (thrombus) are crucial in dictating the deformation and remodeling of a thrombus after its formation in hemostasis. We propose a fully-Eulerian, three-dimensional, phase-field model of thrombus that is calibrated with existing in vitro experimental data. This phase-field model considers spatial variations in permeability and material properties within a single unified mathematical framework derived from an energy perspective, thereby allowing us to study effects of thrombus microstructure and properties on its deformation and possible release of emboli under different hemodynamic conditions. Moreover, we combine this proposed thrombus model with a particle-based model which simulates the initiation of the thrombus. The volume fraction of a thrombus obtained from the particle simulation is mapped to an input variable in the proposed phase-field thrombus model. The present work is thus the first computational study to integrate the initiation of a thrombus through platelet aggregation with its subsequent viscoelastic responses to various shear flows. This framework can be informed by clinical data and potentially be used to predict the risk of diverse thromboembolic events under physiological and pathological conditions.
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spelling pubmed-72245662020-06-01 A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels Zheng, Xiaoning Yazdani, Alireza Li, He Humphrey, Jay D. Karniadakis, George E. PLoS Comput Biol Research Article Mechanical interactions between flowing and coagulated blood (thrombus) are crucial in dictating the deformation and remodeling of a thrombus after its formation in hemostasis. We propose a fully-Eulerian, three-dimensional, phase-field model of thrombus that is calibrated with existing in vitro experimental data. This phase-field model considers spatial variations in permeability and material properties within a single unified mathematical framework derived from an energy perspective, thereby allowing us to study effects of thrombus microstructure and properties on its deformation and possible release of emboli under different hemodynamic conditions. Moreover, we combine this proposed thrombus model with a particle-based model which simulates the initiation of the thrombus. The volume fraction of a thrombus obtained from the particle simulation is mapped to an input variable in the proposed phase-field thrombus model. The present work is thus the first computational study to integrate the initiation of a thrombus through platelet aggregation with its subsequent viscoelastic responses to various shear flows. This framework can be informed by clinical data and potentially be used to predict the risk of diverse thromboembolic events under physiological and pathological conditions. Public Library of Science 2020-04-28 /pmc/articles/PMC7224566/ /pubmed/32343724 http://dx.doi.org/10.1371/journal.pcbi.1007709 Text en © 2020 Zheng et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zheng, Xiaoning
Yazdani, Alireza
Li, He
Humphrey, Jay D.
Karniadakis, George E.
A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels
title A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels
title_full A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels
title_fullStr A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels
title_full_unstemmed A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels
title_short A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels
title_sort three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224566/
https://www.ncbi.nlm.nih.gov/pubmed/32343724
http://dx.doi.org/10.1371/journal.pcbi.1007709
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