Single-nucleus RNA-seq identifies divergent populations of FSHD2 myotube nuclei

FSHD is characterized by the misexpression of DUX4 in skeletal muscle. Although DUX4 upregulation is thought to be the pathogenic cause of FSHD, DUX4 is lowly expressed in patient samples, and analysis of the consequences of DUX4 expression has largely relied on artificial overexpression. To better...

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Detalles Bibliográficos
Autores principales: Jiang, Shan, Williams, Katherine, Kong, Xiangduo, Zeng, Weihua, Nguyen, Nam Viet, Ma, Xinyi, Tawil, Rabi, Yokomori, Kyoko, Mortazavi, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224571/
https://www.ncbi.nlm.nih.gov/pubmed/32365093
http://dx.doi.org/10.1371/journal.pgen.1008754

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224571/
https://www.ncbi.nlm.nih.gov/pubmed/32365093
http://dx.doi.org/10.1371/journal.pgen.1008754

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