Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models

Complex traits are known to be influenced by a combination of environmental factors and rare and common genetic variants. However, detection of such multivariate associations can be compromised by low statistical power and confounding by population structure. Linear mixed effects models (LMM) can ac...

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Detalles Bibliográficos
Autores principales: Bhatnagar, Sahir R., Yang, Yi, Lu, Tianyuan, Schurr, Erwin, Loredo-Osti, JC, Forest, Marie, Oualkacha, Karim, Greenwood, Celia M. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224575/
https://www.ncbi.nlm.nih.gov/pubmed/32365090
http://dx.doi.org/10.1371/journal.pgen.1008766

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224575/
https://www.ncbi.nlm.nih.gov/pubmed/32365090
http://dx.doi.org/10.1371/journal.pgen.1008766

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