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The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition
We examined the feedback between the major protein degradation pathway, the ubiquitin-proteasome system (UPS), and protein synthesis in rat and mouse neurons. When protein degradation was inhibited, we observed a coordinate dramatic reduction in nascent protein synthesis in neuronal cell bodies and...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224698/ https://www.ncbi.nlm.nih.gov/pubmed/32329716 http://dx.doi.org/10.7554/eLife.52714 |