Toll-like Receptor 4 Deficiency Aggravates Airway Hyperresponsiveness and Inflammation by Impairing Neutrophil Apoptosis in a Toluene Diisocyanate-Induced Murine Asthma Model

PURPOSE: Accumulating evidence has suggested that toll-like receptor 4 (TLR4) is critically involved in the pathogenesis of asthma. The aim of this study was to investigate the role of TLR4 in toluene diisocyanate (TDI)-induced allergic airway inflammation. METHODS: TLR4(−/−) and wild-type (WT) C57B...

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Detalles Bibliográficos
Autores principales: Chen, Shuyu, Deng, Yao, He, Qiaoling, Chen, Yanbo, Wang, De, Sun, Weimin, He, Ying, Zou, Zehong, Liang, Zhenyu, Chen, Rongchang, Yao, Lihong, Tao, Ailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225000/
https://www.ncbi.nlm.nih.gov/pubmed/32400128
http://dx.doi.org/10.4168/aair.2020.12.4.608

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