Cargando…

Decreased Vacuolar Ca(2+) Storage and Disrupted Vesicle Trafficking Underlie Alpha-Synuclein-Induced Ca(2+) Dysregulation in S. cerevisiae

The yeast Saccharomyces cerevisiae is a powerful model to study the molecular mechanisms underlying α-synuclein (α-syn) cytotoxicity. This is due to the high degree of conservation of cellular processes with higher eukaryotes and the fact that yeast does not endogenously express α-synuclein. In this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Callewaert, Geert, D’hooge, Petra, Ma, Tien-Yang, Del Vecchio, Mara, Van Eyck, Vincent, Franssens, Vanessa, Winderickx, Joris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225347/ https://www.ncbi.nlm.nih.gov/pubmed/32457789 http://dx.doi.org/10.3389/fgene.2020.00266

Ejemplares similares

The Ca(2+)/Mn(2+) ion-pump PMR1 links elevation of cytosolic Ca(2+) levels to α-synuclein toxicity in Parkinson's disease models
por: Büttner, S, et al.
Publicado: (2013)

Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae
por: Kipanga, Purity N., et al.
Publicado: (2021)

Multiple tethers of organelle contact sites are involved in α-synuclein toxicity in yeast
por: Del Vecchio, Mara, et al.
Publicado: (2023)

A Mitochondria-Associated Oxidative Stress Perspective on Huntington’s Disease
por: Zheng, Ju, et al.
Publicado: (2018)

Yeasts as Complementary Model Systems for the Study of the Pathological Repercussions of Enhanced Synphilin-1 Glycation and Oxidation
por: Seynnaeve, David, et al.
Publicado: (2021)

Dysregulation of Mitochondrial Ca(2+) Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1
por: Debattisti, Valentina, et al.
Publicado: (2019)

Plant vacuole morphology and vacuolar trafficking
por: Zhang, Chunhua, et al.
Publicado: (2014)

A genome-wide imaging-based screening to identify genes involved in synphilin-1 inclusion formation in Saccharomyces cerevisiae
por: Zhao, Lei, et al.
Publicado: (2016)

Ca(2+) regulation of constitutive vesicle trafficking
por: Sargeant, John, et al.
Publicado: (2022)

Vacuolar Sorting Receptor-Mediated Trafficking of Soluble Vacuolar Proteins in Plant Cells
por: Kang, Hyangju, et al.
Publicado: (2014)

The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae
por: Van Rossom, Sofie, et al.
Publicado: (2012)

Synphilin-1 Enhances α-Synuclein Aggregation in Yeast and Contributes to Cellular Stress and Cell Death in a Sir2-Dependent Manner
por: Büttner, Sabrina, et al.
Publicado: (2010)

Ryanodine Receptor Permeation and Gating: Glowing Cinders That Underlie the Ca(2+) Spark
Publicado: (1999)

The Vacuolar Ca(2+) ATPase Pump Pmc1p Is Required for Candida albicans Pathogenesis
por: Luna-Tapia, Arturo, et al.
Publicado: (2019)

Identification of Inhibitory Ca(2+) Binding Sites in the Upper Vestibule of the Yeast Vacuolar TRP Channel
por: Amini, Mahnaz, et al.
Publicado: (2018)

Activity of the yeast vacuolar TRP channel TRPY1 is inhibited by Ca(2+)–calmodulin binding
por: Amini, Mahnaz, et al.
Publicado: (2021)

Recent Insights on Alzheimer’s Disease Originating from Yeast Models
por: Seynnaeve, David, et al.
Publicado: (2018)

Endosome-based protein trafficking and Ca(2+) homeostasis in the heart
por: Curran, Jerry, et al.
Publicado: (2015)

Mechanisms and Regulation of Cardiac Ca(V)1.2 Trafficking
por: Westhoff, Maartje, et al.
Publicado: (2021)

The role of CaMKK2 in Golgi-associated vesicle trafficking
por: Kennedy, Grace, et al.
Publicado: (2023)

Dysregulated Ca(2+) Homeostasis in Fanconi anemia cells
por: Usai, Cesare, et al.
Publicado: (2015)

Multifaceted Roles of ALG-2 in Ca(2+)-Regulated Membrane Trafficking
por: Maki, Masatoshi, et al.
Publicado: (2016)

Ca(V)β-subunit dependence of forward and reverse trafficking of Ca(V)1.2 calcium channels
por: Ferron, Laurent, et al.
Publicado: (2022)

Ca(2+) is a key factor in α-synuclein-induced neurotoxicity
por: Angelova, Plamena R., et al.
Publicado: (2016)

Nitrosative modifications of the Ca(2+) release complex and actin underlie arthritis-induced muscle weakness
por: Yamada, Takashi, et al.
Publicado: (2015)

Elevated Ca(2+) at the triad junction underlies dysregulation of Ca(2+) signaling in dysferlin-null skeletal muscle
por: Lukyanenko, Valeriy, et al.
Publicado: (2022)

Vacuolar-type ATPase: A proton pump to lysosomal trafficking
por: FUTAI, Masamitsu, et al.
Publicado: (2019)

Mechanisms controlling the trafficking, localization, and abundance of presynaptic Ca(2+) channels
por: Cunningham, Karen L., et al.
Publicado: (2023)

The dysregulated expression and functional effect of CaMK2 in cancer
por: He, Qi, et al.
Publicado: (2021)

Dysregulated Ca(2+) Homeostasis as a Central Theme in Neurodegeneration: Lessons from Alzheimer’s Disease and Wolfram Syndrome
por: Callens, Manon, et al.
Publicado: (2022)

Molecular basis of interactions between CaMKII and α-actinin-2 that underlie dendritic spine enlargement
por: Curtis, Ashton J, et al.
Publicado: (2023)

Manganese Suppresses the Haploinsufficiency of Heterozygous trpy1Δ/TRPY1 Saccharomyces cerevisiae Cells and Stimulates the TRPY1-Dependent Release of Vacuolar Ca(2+) under H(2)O(2) Stress
por: Ruta, Lavinia L., et al.
Publicado: (2019)

Dynamic L-type Ca(V)1.2 channel trafficking facilitates Ca(V)1.2 clustering and cooperative gating
por: Ghosh, Debapriya, et al.
Publicado: (2018)

Solution NMR Structure of the Ca(2+)-bound N-terminal Domain of CaBP7: A REGULATOR OF GOLGI TRAFFICKING
por: McCue, Hannah V., et al.
Publicado: (2012)

Methylglyoxal inhibits nuclear division through alterations in vacuolar morphology and accumulation of Atg18 on the vacuolar membrane in Saccharomyces cerevisiae
por: Nomura, Wataru, et al.
Publicado: (2020)

Homeostatic control of slow vacuolar channels by luminal cations and evaluation of the channel-mediated tonoplast Ca(2+) fluxes in situ
por: Pérez, V., et al.
Publicado: (2008)

Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3
por: Sørensen, Jakob B.
Publicado: (2017)

TRPC Channels: Dysregulation and Ca(2+) Mishandling in Ischemic Heart Disease
por: Falcón, Débora, et al.
Publicado: (2020)

Calcium dysregulation in atrial fibrillation: the role of CaMKII
por: Heijman, Jordi, et al.
Publicado: (2014)

Altered Ca(2+) Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease
por: Michelucci, Antonio, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_kpkbbruspebhf47r37vnv9739n