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Data on miRNome changes in human cells exposed to nano- or ionic- forms of Cadmium

The data included in this paper are associated with a research article entitled 'Differences in toxicity, mitochondrial function and miRNome in human cells exposed in vitro to Cd as CdS quantum dots or ionic Cd' [1]. The article concerns the use of miRNAs as biomarkers for engineered nanom...

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Autores principales: Paesano, Laura, Marmiroli, Marta, Bianchi, Massimiliano G., White, Jason C., Bussolati, Ovidio, Zappettini, Andrea, Villani, Marco, Marmiroli, Nelson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225374/
https://www.ncbi.nlm.nih.gov/pubmed/32426426
http://dx.doi.org/10.1016/j.dib.2020.105636
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author Paesano, Laura
Marmiroli, Marta
Bianchi, Massimiliano G.
White, Jason C.
Bussolati, Ovidio
Zappettini, Andrea
Villani, Marco
Marmiroli, Nelson
author_facet Paesano, Laura
Marmiroli, Marta
Bianchi, Massimiliano G.
White, Jason C.
Bussolati, Ovidio
Zappettini, Andrea
Villani, Marco
Marmiroli, Nelson
author_sort Paesano, Laura
collection PubMed
description The data included in this paper are associated with a research article entitled 'Differences in toxicity, mitochondrial function and miRNome in human cells exposed in vitro to Cd as CdS quantum dots or ionic Cd' [1]. The article concerns the use of miRNAs as biomarkers for engineered nanomaterials (ENMs) risk assessment. Two different type of human cells, HepG2 and THP-1, were exposed to different forms of Cadmium: nanoscale, as CdS quantum dots (CdS QDs), and ionic, as CdSO(4) 8/3 –hydrate (Cd(II)). The cells were treated with sub-toxic doses of CdS QDs; 3 µg ml(−1) in HepG2 and 6.4 µg ml(−1) and 50 µg ml(−1) in THP-1, as well as equivalent cadmium doses as Cd(II). In this dataset, changes in expression levels of miRNAs are reported. In addition, GO enrichment analyses of target genes of miRNAs modulated by Cd stress, network analysis of the microRNome and an in silico pathway analysis are also reported. These data enhance and also summarize much of the data independently presented in the research article and therefore, must be considered as supplementary.
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spelling pubmed-72253742020-05-18 Data on miRNome changes in human cells exposed to nano- or ionic- forms of Cadmium Paesano, Laura Marmiroli, Marta Bianchi, Massimiliano G. White, Jason C. Bussolati, Ovidio Zappettini, Andrea Villani, Marco Marmiroli, Nelson Data Brief Biochemistry, Genetics and Molecular Biology The data included in this paper are associated with a research article entitled 'Differences in toxicity, mitochondrial function and miRNome in human cells exposed in vitro to Cd as CdS quantum dots or ionic Cd' [1]. The article concerns the use of miRNAs as biomarkers for engineered nanomaterials (ENMs) risk assessment. Two different type of human cells, HepG2 and THP-1, were exposed to different forms of Cadmium: nanoscale, as CdS quantum dots (CdS QDs), and ionic, as CdSO(4) 8/3 –hydrate (Cd(II)). The cells were treated with sub-toxic doses of CdS QDs; 3 µg ml(−1) in HepG2 and 6.4 µg ml(−1) and 50 µg ml(−1) in THP-1, as well as equivalent cadmium doses as Cd(II). In this dataset, changes in expression levels of miRNAs are reported. In addition, GO enrichment analyses of target genes of miRNAs modulated by Cd stress, network analysis of the microRNome and an in silico pathway analysis are also reported. These data enhance and also summarize much of the data independently presented in the research article and therefore, must be considered as supplementary. Elsevier 2020-04-30 /pmc/articles/PMC7225374/ /pubmed/32426426 http://dx.doi.org/10.1016/j.dib.2020.105636 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Biochemistry, Genetics and Molecular Biology
Paesano, Laura
Marmiroli, Marta
Bianchi, Massimiliano G.
White, Jason C.
Bussolati, Ovidio
Zappettini, Andrea
Villani, Marco
Marmiroli, Nelson
Data on miRNome changes in human cells exposed to nano- or ionic- forms of Cadmium
title Data on miRNome changes in human cells exposed to nano- or ionic- forms of Cadmium
title_full Data on miRNome changes in human cells exposed to nano- or ionic- forms of Cadmium
title_fullStr Data on miRNome changes in human cells exposed to nano- or ionic- forms of Cadmium
title_full_unstemmed Data on miRNome changes in human cells exposed to nano- or ionic- forms of Cadmium
title_short Data on miRNome changes in human cells exposed to nano- or ionic- forms of Cadmium
title_sort data on mirnome changes in human cells exposed to nano- or ionic- forms of cadmium
topic Biochemistry, Genetics and Molecular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225374/
https://www.ncbi.nlm.nih.gov/pubmed/32426426
http://dx.doi.org/10.1016/j.dib.2020.105636
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