Cargando…

Creating New β-Globin-Expressing Lentiviral Vectors by High-Resolution Mapping of Locus Control Region Enhancer Sequences

Hematopoietic stem cell gene therapy is a promising approach for treating disorders of the hematopoietic system. Identifying combinations of cis-regulatory elements that do not impede packaging or transduction efficiency when included in lentiviral vectors has proven challenging. In this study, we d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Morgan, Richard A., Ma, Feiyang, Unti, Mildred J., Brown, Devin, Ayoub, Paul George, Tam, Curtis, Lathrop, Lindsay, Aleshe, Bamidele, Kurita, Ryo, Nakamura, Yukio, Senadheera, Shantha, Wong, Ryan L., Hollis, Roger P., Pellegrini, Matteo, Kohn, Donald B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225380/ https://www.ncbi.nlm.nih.gov/pubmed/32426415 http://dx.doi.org/10.1016/j.omtm.2020.04.006

Ejemplares similares

β-Globin Lentiviral Vectors Have Reduced Titers due to Incomplete Vector RNA Genomes and Lowered Virion Production
por: Han, Jiaying, et al.
Publicado: (2020)

The human ankyrin 1 promoter insulator sustains gene expression in a β-globin lentiviral vector in hematopoietic stem cells
por: Romero, Zulema, et al.
Publicado: (2015)

PGE2 and Poloxamer Synperonic F108 Enhance Transduction of Human HSPCs with a β-Globin Lentiviral Vector
por: Masiuk, Katelyn E., et al.
Publicado: (2019)

Pre-clinical Development of a Lentiviral Vector Expressing the Anti-sickling βAS3 Globin for Gene Therapy for Sickle Cell Disease
por: Poletti, Valentina, et al.
Publicado: (2018)

3′HS1 CTCF binding site in human β-globin locus regulates fetal hemoglobin expression
por: Himadewi, Pamela, et al.
Publicado: (2021)

Coordinated β-globin expression and α2-globin reduction in a multiplex lentiviral gene therapy vector for β-thalassemia
por: Nualkaew, Tiwaporn, et al.
Publicado: (2021)

Loss of balancing selection in the βS globin locus
por: Salih, Niven A, et al.
Publicado: (2010)

Uncovering Enhancer Functions Using the α-Globin Locus
por: Vernimmen, Douglas
Publicado: (2014)

Life cycle of an n-globin pseudogene microsatellite locus
por: Bavarva, Jasmin H., et al.
Publicado: (2013)

Gene Therapy of the β-Hemoglobinopathies by Lentiviral Transfer of the β(A(T87Q))-Globin Gene
por: Negre, Olivier, et al.
Publicado: (2016)

5′HS5 of the Human β-globin Locus Control Region Is Dispensable for the Formation of the β-globin Active Chromatin Hub
por: Chan, Ping Kei, et al.
Publicado: (2008)

Nuclease-mediated gene editing by homologous recombination of the human globin locus
por: Voit, Richard A., et al.
Publicado: (2014)

Controlling long-range genomic interactions to reprogram the β-globin locus
por: Deng, Wulan, et al.
Publicado: (2013)

Evolutionary Constraints in the β-Globin Cluster: The Signature of Purifying Selection at the δ-Globin (HBD) Locus and Its Role in Developmental Gene Regulation
por: Moleirinho, Ana, et al.
Publicado: (2013)

Lentiviral Vectors with Amplified Beta Cell-Specific Gene Expression
por: Shaw, Kit L., et al.
Publicado: (2009)

Binding of Protein Factor CTCF within Chicken Genome Alpha-Globin Locus
por: Kotova, E. S., et al.
Publicado: (2016)

Rapid and Sensitive Assessment of Globin Chains for Gene and Cell Therapy of Hemoglobinopathies
por: Loucari, Constantinos C., et al.
Publicado: (2018)

A Dual Reporter Mouse Model of the Human β-Globin Locus: Applications and Limitations
por: Papadopoulos, Petros, et al.
Publicado: (2012)

Intergenic Transcription, Cell-Cycle and the Developmentally Regulated Epigenetic Profile of the Human Beta-Globin Locus
por: Miles, Joanne, et al.
Publicado: (2007)

Chromatin looping and eRNA transcription precede the transcriptional activation of gene in the β-globin locus
por: Kim, Yea Woon, et al.
Publicado: (2015)

Identification of four novel large deletions and complex variants in the α-globin locus in Chinese population
por: Bao, Xiuqin, et al.
Publicado: (2023)

An insulator embedded in the chicken α-globin locus regulates chromatin domain configuration and differential gene expression
por: Furlan-Magaril, Mayra, et al.
Publicado: (2011)

BRG1 directly regulates nucleosome structure and chromatin looping of the α globin locus to activate transcription
por: Kim, Shin-Il, et al.
Publicado: (2009)

CTCF-mediated transcriptional regulation through cell type-specific chromosome organization in the β-globin locus
por: Junier, Ivan, et al.
Publicado: (2012)

Differential regulation of the α-globin locus by Krüppel-like factor 3 in erythroid and non-erythroid cells
por: Funnell, Alister PW, et al.
Publicado: (2014)

A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus
por: Oudelaar, A. Marieke, et al.
Publicado: (2019)

CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells
por: Chung, Jennifer E., et al.
Publicado: (2019)

The globin gene family of the cephalochordate amphioxus: implications for chordate globin evolution
por: Ebner, Bettina, et al.
Publicado: (2010)

TMEM8 – a non-globin gene entrapped in the globin web
por: Philonenko, Elena S., et al.
Publicado: (2009)

Transmembrane Protein ANTXR1 Regulates γ-Globin Expression by Targeting the Wnt/β-Catenin Signaling Pathway
por: Jin, Tingting, et al.
Publicado: (2022)

Globin genes on the move
por: Hardison, Ross C
Publicado: (2008)

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression
por: Yu, Lei, et al.
Publicado: (2018)

Transcription and Chromatin Organization of a Housekeeping Gene Cluster Containing an Integrated β-Globin Locus Control Region
por: Noordermeer, Daan, et al.
Publicado: (2008)

Nucleosome and transcription activator antagonism at human β-globin locus control region DNase I hypersensitive sites
por: Kim, AeRi, et al.
Publicado: (2007)

Global and Local Manipulation of DNA Repair Mechanisms to Alter Site-Specific Gene Editing Outcomes in Hematopoietic Stem Cells
por: Benitez, Elizabeth K., et al.
Publicado: (2020)

PROTEIN COAGULATION AND ITS REVERSAL : THE PREPARATION OF INSOLUBLE GLOBIN, SOLUBLE GLOBIN AND HEME
por: Anson, M. L., et al.
Publicado: (1930)

The Full Globin Repertoire of Turtles Provides Insights into Vertebrate Globin Evolution and Functions
por: Schwarze, Kim, et al.
Publicado: (2015)

The phenomena of balanced effect between α-globin gene and of β-globin gene
por: Zhong, Liangying, et al.
Publicado: (2018)

Genomic organization and gene expression of the multiple globins in Atlantic cod: conservation of globin-flanking genes in chordates infers the origin of the vertebrate globin clusters
por: Wetten, Ola F, et al.
Publicado: (2010)

Structural polymorphism exhibited by a quasipalindrome present in the locus control region (LCR) of the human β-globin gene cluster
por: Kaushik, Mahima, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_1ukuollkhcrot5plm9pd4r2124